IL-35 is a novel responsive anti-inflammatory cytokine - a new system of categorizing anti- inflammatory cytokines. PLoS One. 2012;7:e33628.Li X, Mai J, Virtue A, Yin Y, Gong R, Sha X, Gutchigian S, Frisch A, Hodge I, Jiang X, ...
IL-10 is an anti-inflammatory cytokine acting in an autocrine fashion in macrophages to limit inflammatory responses by decreasing the production of pro-inflammatory cytokines9,10. Simultaneously, IL-10 increases anti-inflammatory genes, typically in a STAT3 dependent manner10,11,12,13. Furthermore,...
The purpose of the study was to compare the inflammatory cytokine and matrix metalloproteinase (MMP) concentrations in synovial fluid after acute plafond fracture with acute tibial plateau fracture. Between December 2011 and August 2014, we prospectively enrolled patients with acute tibial plateau and pl...
Both clinical and experimental studies suggest a close relation between an inflammatory state and insulin resistance. We investigated the association between cytokine-mediated inflammation (high sensitivity C reactive protein [hsCRP] and interleukin [IL] 6) and insulin sensitivity (insulin-mediated glucose...
Dinarello, C.A. The biological properties of interleukin-1.Eur. Cytokine Netw.5, 517–531 (1994). CASGoogle Scholar O'Neill, L.A. & Dinarello, C.A. The IL-1 receptor/Toll-like receptor superfamily: crucial receptors for inflammation and host defense.Immunol. Today21, 206–209 (2000)...
As this complex regulates pro-inflammatory cytokine activation, it was given the name inflammasome (Martinon and Tschopp, 2004). The role of the 14 human NALP proteins identified is still poorly understood. NALPs form a subfamily of the NACHT-LRR family that includes nucleotide oligomerisation ...
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fasting blood glucose of 94 mg/dL, A1C of 4.8%; exclusion factors include smoking, unstable weight within the last 3 months (>3% weight gain or loss), a diagnosed inflammatory or infectious disease, liver failure, renal dysfunction, cancer, and reported alcohol consumption of >20 gra...
Systemic manifestation of preeclampsia (PE) is associated with circulating factors, including inflammatory cytokines and damage-associated molecular patterns (DAMPs), or alarmins. However, it is unclear whether the placenta directly contributes to the in
Caspase-1 is the inflammatory caspase crucial to canonical inflammasome-mediated pyroptosis and cytokine maturation2. Caspase-11 (also known as caspase-4 or -5 in human), another inflammatory caspase, is the core component of non-canonical inflammasome. Caspase-11 directly acts as a receptor of ...