Iron overload in cirrhosis-HFE genotypes and outcome after liver transplantation[J].HEPATOLOGY 2000,31.Brandhagen DJ, Alvarez W, Therneau TM, et al. Iron overload in cirrhosis-HFE genotypes and outcome after liver transplantation. Hepatology 2000; 31:456-60....
Iron overload in liver disease not associated to hemochromatosis is increasingly recognized in cirrhosis. The aim was to evaluate the relationship between iron overload and the main underlying pathophysiological mechanisms of cirrhosis: liver insuffiency and portal hypertension. Methods:All consecutive ...
However, there has been safety concern of SPIONs with cirrhosis related to excess iron-induced oxidative stress. In this study, the impact of iron overload by SPIONs was assessed on a mouse cirrhosis model. A single dose of SPION injection at 0.5 or 5鈥塵g Fe/kg in the cirrhosis group...
A large alcoholintake (for example, 60gram of alcohol or four glasses of wine or beer daily) was shown to increase the risk of liver cirrhosis by nine-fold in patients with hemochromatosis. Alcohol can also promote the absorption of iron from the intestines, resulting in further iron overloa...
Iron accumulation in the liver is considered to be a co-factor for progression of liver disease. Iron overload can enhance the effects of oxidative stress and influence the natural history of patients with cirrhosis, exposing them to a higher risk of hepatocellular carcinoma. The results of clini...
Iron accumulation in the liver causes scarring of the liver (cirrhosis) and an increased risk of developing liver cancer. Hereditary hemochromatosis is an inherited (genetic) disorder in which there is excessive accumulation of iron in the body (iron overload). It is a common genetic disorder ...
in populations of northern European ancestry.13–15Thalassemia major and other forms of iron-loadinganemiaare importantpublic healthproblems in countries bordering the Mediterranean and in an area extending from Southwest Asia and the Indian subcontinent to Southeast Asia.17Dietary iron overload resulting...
Most experimental and human data support the hypothesis that iron overload is a risk factor for cancer in general and liver cancer in particular. This oncogenic effect could be explained by an overproduction of reactive oxygen species and free radicals. In cirrhosis due to genetic haemochromatosis...
Where HC is recognized sufficiently early to permit adequate removal of iron before cirrhosis has developed, the prognosis is excellent. Thus haemochromatosis as a clinical disease should be preventable in a large proportion of patients. Severe iron overload has been described in juveniles and also...
disorder in which iron silently accumulates, damaging joints and essential organs like the heart, liver and kidneys. Often the iron overload remains undiagnosed until middle age, by which time organs are irreparably damaged...