The endeavours of physicians taxed with the problem of iron deficiency over the last 100 years have successfully eliminated this as an issue of hematological interest. Iron overload, although by no means a new problem, has drawn much more attention over the last few decades. The development of...
Iron accumulation in the liver causes scarring of the liver (cirrhosis) and an increased risk of developing liver cancer. Hereditary hemochromatosis is aninherited(genetic) disorder in which there is excessive accumulation of iron in the body (iron overload). It is a commongenetic disorderamong C...
iron overload due to dysregulated iron absorption and iron store mobilisation. Mutations in the HFE (hereditary Fe) gene are responsible for the vast majority of cases. Inactivation of the hepcidin gene in mice also causes severe iron overload demonstrating the conserved role hepcidin has in ...
1G, H). To examine whether iron overload causes apoptosis in human skeletal muscle cells, we used LDH release detection assay (Supplementary Fig. 1F) and apoptotic cells with compromised plasma membrane detected by image-it DEAD kit (Supplementary Fig. 2G, H) for measuring cell death. The ...
acquired iron overloadanaemia of chronic diseaseanaemia of chronic kidney diseasechelation therapyhereditary haemochromatosisiron refractory iron deficiency anaemiaSummary Iron deficiency is a deficit in total body iron which occurs when the iron requirement, essentially for the production of red blood ...
When someone hastoo muchiron in their blood, this can also create problems. Iron overload is the accumulation of excess iron in body tissues and can cause a disorder calledhemochromatosis. This is unlikely to happen from eating foods rich in iron alone. Instead, hemochromatosis is usually caused...
Iron-overload cardiomyopathy is a prevalent cause of heart failure on a world-wide basis and is a major cause of mortality and morbidity in patients with secondary iron-overload and genetic hemochromatosis. We investigated the therapeutic effects of resv
Iron overload disorders can present as non-specific symptoms and develop gradually but, if untreated, can be very fatal. The common causes includemultiple blood transfusions for chronic anemia and increased iron absorption, including hereditary hemochromatosi...
Iron Overload Causes Arrhythmia and Electrophysiologic Disturbances To test whether iron-overloaded iPSC-CMs would exhibit arrhythmic phenotypes in vitro, we first stained iPSC-CMs with the calcium indicator Fura-2 AM and assessed beat rate, beat duration, and beat-to-beat intervals. More than 60...
In conclusion, there can be several causes of weight loss in kidney transplant patients. Iron overload can come across as a rare cause of weight loss. In these patients, ferritin levels should be checked and diagnosis should be clarified by liver biopsy and gene mutation analysis. 展开 ...