Poly(I:C) and LPS induce distinct IRF3 and NF-kappaB signaling during type-I IFN and TNF responses in human macrophages. J Leukoc Biol. 2008;83(5):1249–57.Reimer T, Brcic M, Schweizer M, Jungi TW. poly (I:C) and LPS induce distinct IRF3 and NF-kappaB signaling during type-I ...
活化的 STING 可迁移并激活 TBK1,诱导 IRF3 和 NF-κB 的磷酸化,从而触发促炎细胞因子的转录。与此相一致,scRNA-seq 数据也显示转录因子 Nfkb1 和 Irf3 的调节子活性在 Gsdmd-/-ApoE-/- 小鼠中降低,这些降低主要发生在 M1 巨噬细胞中。因此,作者推测 GSDMD 在氧化-LDL 诱导的 MPMs 中通过线粒体穿孔调节...
NF-kappa BTRAF6TLR signal transduction involves a MyD88-mediated pathway, which leads to recruitment of the IL-1 receptor (IL-1R)-associated kinase 4 (IRAK4) and Toll/IL-lR translation initiation region domain-containing adaptor-inducing IFN-β-mediated pathway, resulting in the activation of ...
Chemoresistance poses a significant clinical challenge in the treatment of gastric cancer (GC), while its underlying molecular mechanisms are still not fully understood. Post-translational protein modification and abnormal activation of nuclear factor-kappa B (NF-κB) are critical regulators of tumor che...
Kinasing and clipping down the NF-kappa B trail Science, 308 (2005), pp. 65-66 CrossrefView in ScopusGoogle Scholar Wang, 2001 X. Wang The expanding role of mitochondria in apoptosis Genes Dev., 15 (2001), pp. 2922-2933 View in ScopusGoogle Scholar Ye et al., 2002 H. Ye, J.R...
Upon the detection of virus infection, two families of transcription factors are primarily responsible about the upregulation of TI-IFNs expression: nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and interferon regulatory factors (IRFs). The NF-κB family induces both pro...
Post-translational protein modification and abnormal activation of nuclear factor-kappa B (NF-κB) are critical regulators of tumor chemoresistance. This study investigates the role of TNF receptors-associated factors 6 (TRAF6) in 5-Fluorouracil (5-FU) resistant GC. Utilizing short hairpin RNA (sh...
Iwamura, T., et al.Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways.Genes Cells.6(4), 375-388 (2001). tenOever, B. R., Servant, M. J., Grandvaux, N., Lin, R., Hiscott, J.Recognition of the measle...
TBK1 also phosphorylates Iκβα, an inhibitor of the transcription factor NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), marking it for proteasomal degradation; Iκβα degradation releases NF-κB, which translocates together with IRF3 into the nucleus, providing a ...
Phospho-NF-kappa-B p65 (Ser536) (93H1) Rabbit mAb 100ul Phospho-IRF3 (Ser396)抗体,磷酸化干扰素调节因子3 LY294002 (PI3 Kinase Inhibitor) 1.5mg Phospho-Met (Tyr1234/1235) (D26) XP Rabbit mAb 100ul Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb 40ul GAPDH (D16H11)...