Conclusions : There is a need for efficacious AMD therapies that target early disease manifestations such as oxidative stress to prevent disease progression. The method described herein serves as an in vitro platform to test efficacy of drug candidates in preventing oxidative stress-induced cellular ...
Presentation Description : Age-related macular degeneration (AMD) is one of the leading causes of vision loss among the elderly population in the Western world. The condition occurs due to the degeneration of the retinal pigment epithelium (RPE) monolayer that supports photoreceptors in the eye. To...
CFH expression and activity changes are associated with increased risk of age-related macular degeneration (AMD), but the relative contributions of CFH from the retinal pigmented epithelium (RPE) and the choroid are not known. Here we aim to study the effects of CFH in choroid versus RPE using...
选择视网膜色素上皮细胞(RPE)是因为这类细胞的结构和功能对正常视力至关重要。例如,视网膜色素变性(RP)、年龄相关性黄斑变性(AMD)和Stargardt病(STGD)都是视网膜变性疾病,它们的发病机制都与视网膜色素上皮细胞功能障碍有关。 而更重要的是,此前已有研究表明干细胞衍生的RPE细胞能够使人类视网膜变性疾病的临床前模型恢复...
This draws a parallel mechanisms with other retinal degenerative conditions such as age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR). Identifying common mechanisms underlying rare retinal diseases is essential for accessible treatments.Katy Linkens...
Furthermore, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1伪), a regulator of mitochondrial biogenesis and function was repressed, and lower expression levels of NAD-dependent deacetylase sirtuin1 (SIRT1) were found in AMD RPE-iPSC-RPE and AMD Skin-iPSC-RPE as ...
PURPOSE. RPE cell transplantation as a potential treatment for AMD has been extensively investigated; however, in AMD, ultrastructural damage affects both the RPE and its underlying matrix support, the Bruch's membrane (BrM). An RPE monolayer supported by a surrogate scaffold could thus provide a...
A. Modeling the dynamic AMD-associated chronic oxidative stress changes in human ESC and ipsc-derived RPE cells. Investig. Ophthalmol. Vis. Sci. 56, 7480-7488, doi:10.1167/iovs.15-17251 (2015).Modeling the Dynamic AMD-Associated Chronic Oxidative Stress Changes in Human ESC and iPSC-Derived ...
Aims/Purpose: Retinal pigment epithelium (RPE) replacement is a very promising cell‐based therapy for retinal degenerative diseases including age‐related macular degeneration (AMD). RPE dysfunction is the main cause of secondary damage to the photoreceptors. We hereby present RPE implantation into ...
Methods : AMD patient-derived iPS lines of divergent cPRS (6 high, 6 low) were obtained from the NEI/NYSCF AMD iPSC panel. iPSCs were differentiated to RPE and qualified using immunohistochemical and transepithelial resistance (TEER) measurements. Basal levels (C3, C3a) and activities (FH-...