2023年6月21日,从国家药品审评中心(CDE)官网获悉,浙江霍德生物工程有限公司iPSC来源细胞药物产品hNPC01注射液临床试验申请获得默示许可(即IND获批),适应症是:缺血性脑卒中偏瘫后遗症。 值得一提的是,hNPC01细胞注射液采用颅内给药方式...
Derivation of Human Induced Pluripotent Stem Cells from Patients with Maturity Onset Diabetes of the Young Maturity onset diabetes of the young (MODY) is an autosomal dominant disease. Despite extensive research, the mechanism by which a mutant MODY gene results in monogenic diabetes is not yet cle...
iPSCInduced pluripotent stem cellsPluripotentKOSRComplete reprogrammingiPSC technology through transfection of the four transcription factors, Oct4, Sox2, Klf4, and c-Myc, can reprogram somatic cells to pluripotent stem cells, which are similar to embryonic stem cells (ESC). It is currently the most...
2023年6月21日,从国家药品审评中心(CDE)官网获悉,浙江霍德生物工程有限公司iPSC来源细胞药物产品hNPC01注射液临床试验申请获得默示许可(即IND获批),适应症是:缺血性脑卒中偏瘫后遗症。 值得一提的是,hNPC01细胞注射液采用颅内给药方式,是全球首个IND申报获批的iPSC衍生前脑神经前体细胞产品,也是中国首个获得CDE默...
215]. Such epigenetic de-differentiation is undesirable when attempting to recapitulate disease-related phenotypes in vitro and also limits the application of iPSCs to personalized medicine. One way to overcome this loss of aging signatures is to bypass the iPSC stage with direct reprogramming, ...
(Fig.5B; Supplementary Data1), further suggesting a low propensity for tumorigenesis in clinically relevant hfNSC populations. Most potential oncogenic TFs detected in hiPSC-NSCs (Supplementary Table4), as well as critical TFs and signalling molecules driving GBM reprogramming and GSC growth and ...
ISR is a key regulatory mechanism activated by various stress conditions (reviewed in [94]). It is triggered by the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2α), which in turn reduces the levels of the ternary complex eIF2:GTP:Met-tRNAi required for ...
neuronal population, then the homogenous population of sorted or induced mature neurons is likely the adequate model to use. However, it is essential to note that the absence of glia in such a model system might influence the experimental results if the studied mechanism also affects other cell ...
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies. Nat Med. 2017;23:1–13. Article CAS PubMed PubMed Central Google Scholar Prots I, Grosch J, Brazdis R-M, et al. α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synuclein...
However, a shared phenotype and molecular mechanism among iPSC-derived neural cells from patients with SAD has not been described. To explore the pathogenesis of SAD, we generated iPSCs from a larger cohort of SAD patients and age-matched controls. Neural progenitor (NP) cells derived from SAD...