1. ALS iPSC-derived microglia and motor neurons respond to astrocyte-targeted IL-10 and CCL2 modulation 译：ALS iPSC 衍生的小胶质细胞和运动神经元对星形胶质细胞靶向的 IL-10 和 CCL2 调节作出反应 作者列表:Allison RL;Ebert AD 发表日期: 2024 Feb 28 期刊:Hum Mol Genet 影响因子: 3.5 中科院分...
These iPSC lines were differentiated to microglia in order to determine the mechanistic impact of exon-2 skipping on microglia function. Result Exon-2 skipping results in a microglia signature identified in the ex vivo brain. Conclusion The interferon microglia signature may be indicative of a ...
PLX5622 was used to eliminate endogenous microglia in mice through oral and intraperitoneal administration, followed by transplantation of human induced pluripotent stem cell-derived microglia (hiPSC-microglia, iMG) into retinal explants to create a novel ex vivo chimeric model containing xenotransplanted ...
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states Article Open access 11 August 2022 CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model Article 03 March 2025 Data availability Bulk RNA-seq data of hiPSC-deri...
为了揭开这些谜团,来自罗氏公司(F. Hoffmann-La Roche Ltd)等机构的研究人员在《Stem Cell Reports》期刊上发表了题为 “An efficient, non-viral arrayed CRISPR screening platform for iPSC-derived myeloid and microglia models” 的论文。他们成功开发出一种高效、非病毒的阵列 CRISPR 筛选平台,用于诱导多能干...
[3]Haney, Michael S et al. “APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.” Nature vol. 628,8006 (2024): 154-161. doi:10.1038/s41586-024-07185-7
Fig. 1: Generation and characterization of WT and ALS-PFN1 iPSC-derived microglia-like cells (iMGs). aSchematic representation of iMG differentiation protocol. Bone morphogenetic protein 4 (BMP-4), vascular endothelial growth factor (VEGF), and stem cell factor (SCF) are used for embryoid body...
iPSC‐derived neurons and microglia with an African‐specific ABCA7 frameshift deletion have impaired functionThe ATP‐binding cassette, sub‐family A (ABC1), member 7 (ABCA7) gene has been implicated as a risk factor in Alzheimer's disease (AD) across populations. However, the risk effect ...
3、Innate immune activation and aberrant function in the R6/2 mouse model and Huntingtons disease iPSC-derived microglia.（R6/2小鼠模型和亨廷顿病ipsc来源的小胶质细胞的先天免疫激活和异常功能。）发布日期 : 2023-07-07 作者 :Gasser Julien , Gillet Gaelle , Valadas Jorge S , Rouvière Laura , ...
Here, we describe the impact of two traffic-related pollutants, EN590 diesel and compressed natural gas (CNG) on the function of human induced pluripotent stem cell -derived microglia-like cells (iMGLs) in vitro. Our data show that microglia exhibit robust, yet pollution-dependent responses to...