Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways Zixuan Li, Qian Ran, Chuan Qu, Shan Hu, Shengyu Cui, You Zhou, Bo Shen & Bo Yang Biology Direct volume...
结论:IP 3R-Grp75-VDAC1-MCU钙轴分子高表达伴mTORC1过度活化参与ADR大鼠肾病模型蛋白尿发生,mTORC1抑制剂显著抑制足细胞钙轴分子表达,可能参与mTORC1抑制剂所致足细胞效应机制.doi:10.3760/cma.j.cn101070-20200613-00987王斯斯北京大学第一医院管娜北京大学第一医院许晗北京大学第一医院魏骐骄北京大学第一医院陶...
The mechanism of podocyte apoptosis is not fully understood. In addition, the role of the inositol 1,4,5-triphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)/mitochondrial calcium uniporter (MCU) cal
目的观察复方地黄颗粒对帕金森病(PD)阴虚动风证大鼠肝脏和结肠组织DJ-1,肌醇1,4,5-三磷酸受体(IP3R),葡萄糖调节蛋白75(GRP75),电压依赖性阴离子通道1(VDAC1)表达的影响.方法采用右侧黑质注射6-羟基多巴胺法制备PD阴虚动风证大鼠模型,将造模成功的65只大鼠随机分为模型组,美多芭组(美多芭150 mg/kg)和中药...
The outer mitochondrial membrane protein VDAC interacts with the ER protein IP3R via chaperone Grp75 to form a molecular complex that couples mitochondria to the ER and contributes to functional mitochondria-ER contacts (MERCs), essential for efficient calcium (Ca2+) transfer. A new study by Liu...
A new study by Liu et al. identifies the PD protein DJ-1 as a component of the IP3R-Grp75-VDAC complex. DJ-1 ablation impairs mitochondria-ER association and Ca2+ crosstalk, and impacts the stability of the trio. 关键词: Parkinson's disease DJ-1 MERCs Calcium (Ca2+) 年份: 2020 ...
WITHDRAWN: Ip3r-Grp75-Vdac and Relevant Ca 2+ Signaling RegulateDietary Palmitic Acid-Induced De Novo Lipogenesis by Mitochondria-Associated ER Membrane (MAM) Recruiting Seipin inYellow CatfishThis article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes...
目的:分析1,4,5三磷酸肌醇受体(IP\n3R)-葡萄糖调节蛋白75(Grp75)-电压依赖性阴离子通道1(VDAC1)-线粒体钙单向转运体(MCU)钙轴分子在肾病蛋白尿时表达变化,探讨其上游调控路径.\n方法:将SD大鼠分为对照组(6只)和阿霉素(ADR)组(10只).通过尾静脉1次注射ADR法建立肾病模型.采用免疫组织化学染色分析肾小球...
Results: The key findings were: (1) Hepatocellular MERCs sub-proteome analysis confirmed that, via activating Ip3r-Grp75-voltage-dependent anion channel (Vdac) complexes, excessive dietary PA intake enhanced hepatic MERCs. (2) Dietary PA intake caused hepatic neutral lipid deposition by MERCs ...
A new study by Liu et al. identifies the PD protein DJ-1 as a component of the IP3R-Grp75-VDAC complex. DJ-1 ablation impairs mitochondria-ER association and Ca2+ crosstalk, and impacts the stability of the trio.Basso, ValentinaMarchesan, ElenaZiviani, Elena...