IP3R-GRP75-VDAC1 channelβ-caroteneEndoplasmic reticulum (ER) and mitochondria are the main sites for the storage and regulation of Ca 2+ homeostasis . An imbalance of Ca 2+ homeostasis can cause ER stress and
Ctl, control; ADR, Adriamycin; Ang II, angiotensin II; IP3R, inositol 1,4,5-triphosphate receptor; Grp75, glucose-regulated protein 75; VDAC1, voltage dependent anion channel 1; MCU, mitochondrial calcium uniporter; a, compared with the Ctl group; **, P < 0.01; *, P < 0.05...
内质网与线粒体通讯的接触点称为线粒体相关内质网膜(MAM)，研究表明，电压依赖性阴离子通道1（VDAC1）通过MAM相关的葡萄糖调节蛋白75 (GRP75，或热休克蛋白家族A成员9 [HSPA9])与三磷酸肌醇受体(IP3R1)连接，GRP75直接调控钙从内质网向线粒体的转移。在心衰和缺血/再灌注(I/R)损伤中，钙信号在兴奋-收缩耦联...
The outer mitochondrial membrane protein VDAC interacts with the ER protein IP3R via chaperone Grp75 to form a molecular complex that couples mitochondria to the ER and contributes to functional mitochondria-ER contacts (MERCs), essential for efficient calcium (Ca2+) transfer. A new study by Liu...
Conclusions: The findings of this study provide a new insight into the regulatory role of MERCS-recruited SEIPIN in hepatic lipid synthesis via Ip3r-Grp75-Vdac complex-mediated Ca2 signaling, highlighting the critical contribution of MERCS in hepatic lipid homeostasis....
A new study by Liu et al. identifies the PD protein DJ-1 as a component of the IP3R-Grp75-VDAC complex. DJ-1 ablation impairs mitochondria-ER association and Ca2+ crosstalk, and impacts the stability of the trio.Basso, ValentinaMarchesan, ElenaZiviani, Elena...