Patch clamp techniques for studying ionic channels in excitable membranes. Ann. Rev. Physiol. 46, 455–472 (1984). CAS Google Scholar Hille, B. Ionic Channels Of Excitable Membranes 2nd edn (Sinauer Associates, 1992). Hille, B. Ion Channels Of Excitable Membranes 3rd edn (Sinauer Associates...
All-optical interrogation of neural circuits in behaving mice Article 27 April 2022 References Hille, B. Ionic Channels of Excitable Membranes 3rd edn (Sinauer Associates, 2001). Lemoine, D. et al. Ligand-gated ion channels: new insights into neurological disorders and ligand recognition. Chem...
Revealing the architecture of protein complexes by an orthogonal approach combining HDXMS, CXMS, and disulfide trapping Article 24 May 2018 References Hille B (2001) Ion channels of excitable membranes, 3rd edn. Sinauer associates, Sunderland, MA Google Scholar Khakh BS, North RA (2006) P2X...
from prokaryotes to humans. Voltage-gated ion channels for Na+, Ca2+, K+, and Cl−are responsible for action potential generation in electrically excitable cells, and for regulation of membrane potential and intracellular Ca2+levels in other cell types. These channels are composed of pore-formin...
Ion Channels of Excitable Membranes 3rd edn (Sinauer, 2001). 19. Voets, T. & Nilius, B. The pore of TRP channels: trivial or neglected? Cell Calcium 33, 299–302 (2003). 20. Brelidze, T. I., Niu, X. & Magleby, K. L. A ring of eight conserved negatively charged amino acids...
In many species, excitable cells preserve their physiological properties despite significant variation in physical size across time and in a population. For example, neurons in crustacean central pattern generators generate similar firing patterns despit
Electrical signaling by ion channels is a fundamental cellular regulatory pathway in all organisms from prokaryotes to humans. Voltage-gated Na+(VGSC), Ca2+(VGCC), and K+(VGPC) channels are responsible for action potential generation in electrically excitable cells, for example, neurons and muscle...
Chloride homeostasis is regulated in all cellular compartments. CLC-type channels selectively transport Cl− across biological membranes. It is proposed that side-chains of pore-lining residues determine Cl− selectivity in CLC-type channels, but the
channels such as TRPM2 channel7, CNG channel36, HCN channel37, and BK channel5, where ADPR, cAMP, and calcium ions, respectively, bind to the intracellular domains to trigger pore opening. Based on spectroscopic imaging of ANAP labeled at specific sites and computational modeling constrained ...
The selective transport of ions across cell membranes, controlled by membrane proteins, is critical for a living organism. DNA-based systems have emerged as promising artificial ion transporters. However, the development of stable and selective artificia