Excitability of cell membranes is crucial for signaling in many types of cell. Excitation in the physiological sense means that the cell membrane potential undergoes characteristic changes which, in most cases, go in the depolarizing direction. Single depolarization from the resting potential to ...
Membrane potential-dependent ion channels in cell membranes by S. Hagiwara. Raven Press, New York, 1983, 118 pp. $00.00.doi:10.1002/neu.480140611Monte WesterfieldThe Institute of Neuroscience University of Oregon Eugene, OregonJohn Wiley & Sons, Inc.Developmental Neurobiology...
Ion channels in the plasma membrane play a critical role in cellular function. These proteins are the gatekeepers that control ion homeostasis and shape excitability. Excitable cells use a variety of different ion channels to fashion their hallmark elect
Within a few years, the elementary events induced by some transmitters in mammalian CNS neurons will become amenable to study without the need for cell dissociation and culture methods. This achievement will realize one of the long-standing goals of cellular neurobiology. 展开 关键词:...
摘要: Introduction ion channels are macromolecular pores in cell membranes. When they evolved and what role they may have played in the earliest forms of life we still do not know, but today ion channels are most obvious as the fundamental excitable elements in the关键词: Ion channels....
Patch clamp techniques for studying ionic channels in excitable membranes. Ann. Rev. Physiol. 46, 455–472 (1984). CAS Google Scholar Hille, B. Ionic Channels Of Excitable Membranes 2nd edn (Sinauer Associates, 1992). Hille, B. Ion Channels Of Excitable Membranes 3rd edn (Sinauer Associates...
Ion channels involved in processes such as electrical signaling across the cell membrane display tightly regulated activation. For example, the generation of an action potential requires that voltage-gated Na+ channels open fast to allow Na+ influx into the cell in order to rapidly depolarize the ...
Currents were partially inhibited by the hERG blockers E4031, verapamil, and clofilium, indicating that the protein of interest is present at high levels in the BLM relative to endogenous channels. Cell liposomes produced from Sf9 insect cell membranes expressing voltage-gated sodium channels also...
Chapter 3 Cell Membrane Transport Mechanisms: Ion Channels and Electrical Properties of Cell MembranesCellular life strongly depends on the membrane ability to precisely control exchange of solutes between the internal and external (environmental... J Kulbacka,A Choromanska,J Rossowska,... - 《Advance...
Ion channels are specific membrane proteins present in all cell membranes and some organelle membranes (e.g., mitochondria, Golgi apparatus, endoplasmic reticulum and lysosomes) (Wu et al. 2019; Tao et al. 2016). Ion channel genes encode these specific membrane proteins (mainly pore-forming memb...