Semi-invariant T cell receptors (TCRs) found on natural killer T (NKT) and mucosal-associated invariant T (MAIT) cells are characterized by the use of invariant variable (V) and joining (J) gene combinations in the TCR α-chain, as well as ubiquitous canonical TCRα amino acid sequences...
One subset of canonical T cells is restricted by CD1d, a non-classical antigen presenting molecule that presents lipids and glycolipids. Canonical CD1d-restricted T cells have semi-invariant TCR consisting of an invariantly rearranged TCR alpha chain, paired with diversely rearranged TCR beta chains....
One subset, known as invariant NKT (iNKT) cells, expresses an invariant T cell recptor α (TCRα) chain paired with a limited number of TCRβ chains. This TCR recognizes lipids presented by the nonclassical MHC I–like molecule CD1d. Although iNKT cells are thought to arise from the same...
T cell receptor (TCR) signaling regulates important developmental transitions, partly through induction of the E protein antagonist, Id3. Although normal γδ T cell development depends on Id3, Id3 deficiency produces different phenotypes in distinct γδ T cell subsets. Here, we show that Id3 def...
The invariant (i) natural killer (NK)T cells consistently express the V伪14 chain of the T cell receptor (TCR) and recognize 伪-galactosylceramide (伪-GalC... AM Vannucchi,P Guglielmelli - 《American Journal of Hematology》 被引量: 0发表: 2018年 The role of lipid transporter MFSD2A in...
and siRNA specific for Ii chain of DCs was transfected by lipofection.DCs were further matured with or without TNF-α at a concentration of 50 ng/mL for 48 h.The silencing effect of siRNA was evaluated by Western blotting.The cell morphology and viability were detected by light microscopy,...
Mucosal-associated invariantT cells(MAIT cells) are a unique subset of innate T cells expressing an invariantTCRα chaincomposed of Vα7.2. They are found in small numbers in human peripheral blood but are enriched in gut, lung and liver where they constitute up to 50% of all T cells[160...
TCRCurrent models of the TCR / CD3 complex assume that, in mature peripheral T lymphocytes, variability is restricted to the chain pairing. Rather, they are linked to heterogeneity of the N-terminal region of CD3ϵ chains, as detected by peptide-specific antibodies. In turn, these...
This invariant Vc~24 chain is always paired to V311. This unique Ve~24-Jc~Q/V311 TCR was found in expanded DN clones from all the individuals tested. These findings suggest that the frequent occurrence of cells carrying this invariant TCR. is due to peripheral expansion of rare clones ...
A novel T cell subset characterized by cell surface NK1.1+ TCR alpha beta+ expression was investigated for its TCR alpha usage, particularly that of invariant V alpha 14 TCR, which was found to be preferentially used in peripheral CD4-CD8- T cells developed at extrathymic sites. We found th...