(2011) Invariant chain increases the half-life of MHC II by delaying endosomal matura- tion. Immunol. Cell Biol. 89, 619 - 629.Landsverk, O.J.B.; Barois, N.; Gregers, T.F.; Bakke, O. Invariant chain increases the half-life of MHC II by delaying endosomal maturation. Immunol. ...
网络释义 1. 恒定链 恒定链(Invariant Chain,Ii)是一种非多态性Ⅱ型跨膜糖蛋白,它是MHCⅡ分子生物合成及MHCⅡ分子结合外源性抗原肽过程中重 … www.shangxueba.com|基于8个网页
Invariant chain is a nonpolymorphic, non–MHC-encoded type II membrane glycoprotein protein that associates with class II during biosynthesis. It contributes several discrete functions to the biogenesis and function of MHC class II molecules.20 Many of the functions of the invariant chain are conveyed...
The resulting mature MHC II–peptide complexes are ultimately released to the cell surface for recognition by CD4+ Th cells. 2. Within the endoplasmic reticulum 2.1. Structure of the Ii chain Ii chain is a non-polymorphic type II integral membrane protein, where the N-terminus constitutes a ...
untreatedcells.TheseresultssuggestthatIiassociatedwithclassIIantigensonRCCmaycontributetotheanti-tumorimmuneresponseofthehostandthatIFN-K,whichisadministeredforthetreatmentofcancer,mayincrealsetheimmunogenicityofRCC.Keywords:Renalcellcancer;Invariantchain;Majorhistocompatibilitycomplex(MHC);Tumor-infiltratinglymphocytes(...
MHC class II Invariant chain Thyroglobulin type-1 repeat Zebrafish Access this article Log in via an institution Subscribe and save Springer+ Basic €32.70 /Month Get 10 units per month Download Article/Chapter or eBook 1 Unit = 1 Article or 1 Chapter Cancel anytime Subscribe now Buy Now...
We conclude that in untreated cells, cleavage and release of Ii from class II MHC alpha and beta chains occur after those complexes traverse a BFA-sensitive step in the Golgi apparatus. 展开 关键词: BFA Brefeldin A Endo-H endoglycosidase H ER endoplasmic reticulum I i invariant chain ...
Invariant chain (Ii) contributes in a number of distinct ways to the proper functioning of major histocompatibility complex (MHC) class II molecules. These... Romagnoli,P. - 《Journal of Experimental Medicine》 被引量: 348发表: 1994年 Expression of endogenous peptide-major histocompatibility complex...
The invariant chain (Ii) chaperone for MHC class II molecules is crucial for their effective function. Equally important is its removal. Cathepsins S or L are known to be required for the final stages of Ii removal in different APCs, but the enzymes which initiate Ii processing have not bee...
The MHC class II-associated invariant chain (Ii), also known as CD74, is found recruited to MV in DC [10]. A non-polymorphic type II transmembrane protein, Ii has many important functions in DC and other cells [16], [17], [18], [19], [20], [21]. When DC undergo maturation,...