1、对于仅接受化疗的成人inv(16)AML患者,初诊KITMU、FLT3-ITD+和巩固治疗2个疗程后MRD高水平(CBFB–MYH11 mRNA水平>0.2%)均是复发的独立不良预后因素。 2. 联合初诊KIT突变、FLT3-ITD突变表现和巩固治疗2个疗程后MRD水平将患者分...
Treatment-related AML (t-AML) accounts for approximately 7% of patients with AML. The most common cytogenetic abnormalities seen in t-AML include chromosome 5 and 7 abnormalities (as seen with alkylating agents) and MLL translocations (as seen with topolsomerase inhibitors). Inversion 16 (inv(...
inv(16)(p13q22)主要见于急性髓系白血病(acute myelogenous leukemia,AML)M 4Eo患者,对于CML是极其罕见的染色体畸变 [2]。目前文献报道较少,其临床特点、治疗策略及预后仍不十分清楚。丽水市人民医院收治1例伊马替尼治疗过程中罕见CML的急单变合并inv(16)(p13q12)罕见染色体畸变的患者,结合相关文献报道如下。
In particular, it has been reported that acute myeloid leukemia (AML) patients with inv(16) abnormality show a better prognosis, especially in case of treatment with high-dose Ara-C (HD Ara-C) containing regimens. In this study we aimed at testing whether leukemic cells from patients showing...
方法:对 43 例 AML 伴 Inv(16)/ t(16;16)患者进行总结分析、随访, 了解一般情况、免疫分型、染色体核型及治疗、生存情况, 对影响总体生存时间、无复发生存时间的因素进行统计学分析。 结果:43 例AML 伴 Inv(16)/ t(16;16)患者总完全缓解(CR)率 97.5%, ... ...
30 Deaths occurring during the induction course and resistant AML after the induction course were classified as induction failures. Postremission therapy The impact of postremission therapy on outcome was analyzed using the intent-to-treat principle (treatment allocated at CR achievement). Postremission...
Treatment of AML in biological subgroups. Hematology 2005; 10 (Suppl 1): 281–285. Article Google Scholar Evans PA, Short MA, Jack AS, Norfolk DR, Child JA, Shiach CR et al. Detection and quantitation of the CBFbeta/MYH11 transcripts associated with the inv(16) in presentation and ...
16p13/16q22arefoundintheM4eosubtype:i.e.this anomaly,althoughmainlyfoundinM4-ANLL inv(16)(p13q22),t(16;16)(p13;q22),del(16)(q22)HuretJL AtlasGenetCytogenetOncolHaematol.1999;3(3) 148 Patientswithinv(16)usuallycorrespondtothesubclassofAMLM4,withaspecificabnormaleosinophilcomponentandisconsidered...
方法选用针对鼠疫菌F1抗原基因、pla基因、inv基因和一段鼠疫特异染色体序列设计的4对引物,以鼠疫菌及其他肠道致病菌DNA为模板并加入内部对照模板,在同一扩增体系中进行PCR扩增。 5) inv(16) AML inv(16)AML 6) Inventory 库存(INV) 参考词条 冗余INV优化三硝基困醇线粒体12SrRNA基困不亲和性等位基困机制通信窗口...
Heterogeneity in CBF beta/MYH11 fusion messages encoded by the inv(16)(p13q22) and the t(16;16)(p13;q22) in acute myelogenous leukemia Inv(16)(p13q22) is one of the most frequent chromosomal rearrangements found in acute myelogenous leukemia (AML), representing approximately 16% of documen...