Saulnier N, Viguier E, Perrier-Groult E, Chenu C, Pillet E, Roger T, Maddens S, Boulocher C (2015) Intra-articular administration of xenogeneic neonatal Mesenchymal Stromal Cells early after meniscal injury down-regulates metalloproteinase gene expression in synovium and pre- vents cartilage ...
We found that the intra-articular administration of 500nM and 5M BMS-345541 significantly suppressed OA development. In the BMS-345541-treated cartilage, there was a decrease in the phosphorylation of IκBα and the expression of Hif-2α, Mmp13, and Adamts5. In human articular chondrocytes, ...
effects of intra-articular administration of rapamycin using biode- gradable hydrogels in a murine OA model, we created gelatin hydrogels incorporating rapamycin-micelles. 2. Materials & methods 2.1. Gelatin hydrogels incorporating rapamycinemicelles Rapamycin was provided by LC Laboratories (Woburn, MA,...
Here, we showed that the intra-articular administration of an IKK inhibitor could regulate the development of surgically-induced OA of the knee in mice. Histological analyses indicated that the activity of NF-κB was decreased in articular cartilage treated with the IKK inhibitor before OA developmen...
RFQ administration in the rats resulted in reduced knee swelling and expression of systemic inflammatory markers, a decrease in signs of femoral osteomyelitis and decreased biofilm formation. Doses of RFQ in both species were statistically more effective than vancomycin in reducing the bacterial burden....
Following a single dose of IA administration of 3 mg/kg of RFQ in dogs, the Cmax in plasma was 736 ng/mL, while the mean synovial fluids concentrations at 12 and 36 hours post dosing were 77,300 and 2,240 ng/mL, respectively. The synovial fluid concentration were 38.7 and 1.12 fold ...
Pre-emptive intra-articular administration of local anaesthetics/opiates versus postoperative local anaesthetics/opiates or local anaesthetics in arthrosco... Hein,H. O. Mayr.Pre-emptive intra-articular administration of local anaesthetics/opiates versus postoperative local anaesthetics/opiates or local ...
Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge medical and socioeconomic burdens. Intra-articular administration of agents is clinically used for pain management. However, the effectiveness is inapparent caused by the rapid clearance of agents. To overcome ...
Meaning Compared with placebo, intra-articular administration of 100 μg of sprifermin every 6 or 12 months resulted in improvement in femorotibial joint cartilage thickness after 2 years that was statistically significant, but of uncertain clinical importance; the durability of response also was uncert...
This study investigated whether a single intra-articular administration (IA) of dexamethasone (DEX) in horses at therapeutic dosage could exert a systemic effect by influencing the hypothalamic-pituitary-adrenal axis activity as a consequence of (limited) absorption and systemic distribution. The results...