Comparison of efficacy of intra-articular and intravenous route of administration of tranexamic acid in reducing blood loss in total knee arthroplastyLALCHANDANI, RAJESHTANDON, RAGHAVKRISHNAN, ROHANIndian Journal of Basic & Applied Medical Research
We found that the intra-articular administration of 500nM and 5M BMS-345541 significantly suppressed OA development. In the BMS-345541-treated cartilage, there was a decrease in the phosphorylation of IκBα and the expression of Hif-2α, Mmp13, and Adamts5. In human articular chondrocytes, ...
Although the ADAMTS class of enzymes have clearly been implicated in OA progression,64-66 evidence for a significant role of MMP gene upregulation is persuasive and imparts a major role for this enzyme class in the destruction of articular cartilage and resultant joint failure.67,68 Thus, the ...
Effects of intra-articular administration of BMS-345541 in surgically-induced mouse knee osteoarthritis (OA). (a) Schematic representation of the surgical procedure for OA induction, intra-articular injections, and time of sacrifice. Injections were performed three times a week after surgery for 8 we...
Comparison of the efficacy of intraarticular administration of lornoxicam, bupivacaine and placebo on postoperative analgesia after arthroscopic knee surgerydoi:10.1016/j.rapm.2004.07.174K. Koltka and G.K. Talu and M Cengız and Ş Yildirim and S Özyalçin...
This study investigated whether a single intra-articular administration (IA) of dexamethasone (DEX) in horses at therapeutic dosage could exert a systemic effect by influencing the hypothalamic-pituitary-adrenal axis activity as a consequence of (limited) absorption and systemic distribution. The results...
Pain following arthroscopic knee surgery remains a controversial clinical problem. Intra-articular (IA) glucocorticoid injections have demonstrated the potential to provide better analgesia in some orthopedic surgeries; however, due to the lack of studie
The optimal route of administration of glucocorticoid for pain management following orthopedic surgeries has been a topic of research. The perineural approached has been reviewed in the meta-analysis by Albrecht et al. [38] and has been observed to associated with prolonged duration of analgesia, re...
(group B,n=37),and intra-articular injection of parecoxib+basic treatment+oral glucosamine(group C,n=36).Intra-articular injection of parecoxib was performed once every 2 wk at a dose of 40 mg each time,for three times total.The three groups were compared in terms of visual analogue scale...
[52]. The application of SLNs in parenteral delivery ranges from intraarticular delivery route to intravenous administration[5]. Various researchers have performed investigations on intravenous performance of SLNs[14,41]. Zara et al. investigated the effects of stealth and nonstealth SLNs ...