Interleukin-6 (IL-6) has been long considered a key player in cancer cachexia. It is believed that sustained elevation of IL-6 production during cancer progression causes brain dysfunctions, which ultimately result in cachexia. However, how peripheral IL-6 influences the brain remains poorly unders...
Interleukin-6 (IL6) expression increases in atrophying muscles and lung tissue during compromised function. Considering ALS patients undergo these same pathological changes, IL6 levels may be relevant for prognostication and treatment. The amount of soluble IL6 receptor, dictated by the IL6R358Ala ...
We propose that the explanation lies in IL-6’s ability to coordinate short-term energy allocation, especially during sustained, strenuous endurance PA. IL-6 is a good candidate for a short-term energy allocator for several reasons. Like other short-term energy allocators, IL-6 has a relative...
6 knockout (IL-6−/−) mice could not strongly suppress allo-T-cell proliferation in anMLRassay. These data demonstrated that mMSC-derived IL-6 also mediated their immunoregulatory properties[50,51]. The mMSC-derived IL-6 may also interfere with DC maturation, decreasing DC function of...
白细胞介素一6肿瘤坏死 3) White Blood Cell 白细胞 1. Association of white blood cell count with cardiac function and mortality in elderly patients with acute myocardial infarction; 老年急性心肌梗死患者白细胞计数与心脏功能及在院死亡率的关系
Interleukin-6 (IL-6), a member of the neuropoietic cytokine family, initially was described in terms of its activities in the immune system and during infl... RA Gadient,UH Otten - 《Progress in Neurobiology》 被引量: 952发表: 1997年 The function of the soluble interleukin 6 (IL-6) re...
In fact, a soluble IL-6-R lacking the transmembrane and intracytoplasmic domains can associate with gp130 in the presence of IL-6 and mediate its function. These findings indicate that the complex of IL-6 and IL-6-R can interact with a non-ligand-binding membrane glycoprotein, gp130, ...
IL-6, granulocyte colony-stimulating factor, CXCL1 and CXCL2 through activation of the actin related gene 1-TNF receptor associated factor 6–nuclear factor-jB axis in the downstream.The function of IL-17 is pleiotropic . It plays a crucial role in the host defence against bacterial and funga...
Recent findings indicate that interleukin-1 (IL-1) and interleukin-6 (IL-6), cytokines secreted by immunologically activated monocytes and macrophages modulate neuroendocrine function. The site of production (centrally, peripherally), the site of action and the physiological significance of IL-1 and ...
Thus, we now investigated if IL-6 influences the expression and function of neuronal adenosine A1receptorsin vitroandin vivo. Looking at three different pathological conditions in which adenosine has proven to be implicated as a protective agent—hypoxia, glutamate-induced cell death, and seizures—...