PLEIOTROPY AND REDUNDANCY OF INTERLEUKIN-6 (IL-6) AND RELATED CYTOKINES IL-6 RECEPTOR (IL-6R) DISCOVERY OF gp130 gp130 AS A COMMON CYTOKINE SIGNAL TRANSDUCER RECEPTORS BELONGING TO THE gp130 FAMILY A UNIQUE CYTOKINE RECEPTOR SYSTEM MECHANISM OF THE SIGNAL TRANSDUCTION THROUGH gp130 THE TRANSCRIPT...
IL-6-type cytokines belong to a family of four helical cytokines with a unique protein fold [2, 74, 79]. Receptors for these cytokines are proteins with several immunoglobulin (Ig-) and fibronectin type-III domains. Two of these fibronectin type III domains form a cytokine-binding domain ...
The interleukin-6 (IL-6) family of cytokines includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine (CLC) and cardiotrophin-1 (CT-1). The IL-6 family cytokines exhibit a four-helix bundle structure. In...
The interleukin-6 (IL-6) family of cytokines includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine (CLC) and cardiotrophin-1 (CT-1). The IL-6 family cytokines exhibit a four-helix bundle structure. In...
The IL-6 family of cytokines recruits gp130 for signaling (Figure 1). Thus, the family is also known as the gp130 family of cytokines. This protein has also a modular architecture, part of which has features typical of the cytokine receptors (two fibronectin type III modules containing ...
IL-6 (interleukin 6), originally discovered as a B-cell differentiation factor, is a multifunctional pleiotropic cytokine that regulates immune response, acute-phase response, hematopoiesis, and inflammation. Sino Biological offers premium biological products including IL-6 protein, IL-6 antibody, IL-...
The interleukin 6 (IL-6) cytokine family, which includes IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), IL... M Hibi,K Nakajima,T Hirano - 《Journal of Molecular Medicine》 被引量: 510发表: 1996年 Differential regulation of interleukin-10...
IL-6 in inflammation, autoimmunity and cancer. Int. Immunol. 33, 127–148 (2021). Article CAS PubMed Google Scholar Putoczki, T. L. et al. Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell 24, 257–...
which fall into a 2-stranded anti-parallel beta-sheet. The fourth alpha helix is important to the biological activity of the molecule. Interleukin-6 (IL-6) is an important proinflammatory and immunoregulatory cytokine expressed by various cells. Interleukin-6 has been shown to inhibit the growth...
Interleukin(IL)-11 is a member of the IL-6 family of cytokines that comprises nine secreted soluble ligands; IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin-M (OSM), ciliaryneurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), interleukin-27 (IL...