1.Any of a group of glycoproteins that are produced by different cell types in response to various stimuli, such as exposure to a virus, bacterium, parasite, or other antigen, and that inhibit infection through mechanisms such as preventing viral replication or regulating the immune system. ...
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Type I interferons can be produced by almost any cell upon stimulation by a virus; their primary function is to induce viral resistance in cells. Type II interferon is secreted only by natural killer cells and T lymphocytes; its main purpose is to signal the immune system to respond to ...
et al. Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy. Nat Immunol 23, 1273–1283 (2022). https://doi.org/10.1038/s41590-022-01262-7 Download citation Received19 July 2021 Accepted09 June 2022 Published14 July 2022 ...
ZlatkoDembic, inThe Cytokines of the Immune System, 2015 Abstract Interferonswere initially defined as a group of cytokines produced by any type of cell in the body in response to viral infection. Their essential link with the innate and adaptiveimmune systemhas been established only recently to ...
Interferons (IFNs) are critical soluble factors in the immune system and are composed of three types, (I, II and III) that utilize different receptor complexes IFN-αR1/IFN-αR2, IFN-γR1/IFN-γR2, and IFN-λR1/IL-10R2, respectively. Here we identify IFN-υ from the genomic sequence...
Intriguingly, innate immune response plays a central role in controlling both the membrane fusion and endosomal viral entry with undisrupted cellular homeostasis and safeguards the non-infected cells from pathogenicity followed by initiating adaptive immunity. Hence, the innate immune system acts as the...
AdelinePeignier,DaneParker, inTrends in Microbiology, 2021 Introduction Interferons(IFNs) are a broad class of pleiotropic cytokines elicited upon encounter of the innateimmune systemwith pathogens. These innate immune mediators owe their name to the initial observation that they could 'interfere' with...
Interferons(IFNs) are proteins made and released by host cells in response to the presence of pathogens—such as viruses, bacteria, or parasites—or tumor cells. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. ...
Epstein, The Effects of Interferons on the Immune Response in Vitro and in Vivo Interf. and Therhetions, 1977, CRC Press, Cleveland, pp. 114-121. Primary Examiner: Wiseman; Thomas G. Assistant Examiner: McCowin; Kathleen S. Attorney, Agent or Firm: ...