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Type I interferons can be produced by almost any cell upon stimulation by a virus; their primary function is to induce viral resistance in cells. Type II interferon is secreted only by natural killer cells and T lymphocytes; its main purpose is to signal the immune system to respond to ...
immune defense. Three types of interferons are mentioned with respect to their structure and function.Type I interferons(a group consisting of interferons α/β/ω and τ) and type II (interferon-γ) are described for their role in immunologic reactions, association with various diseases and ...
Targeting type I interferon–mediated activation restores immune function in chronic HIV infection. J. Clin. Invest. 127, 260–268 (2017). Article PubMed Google Scholar Sumida, T.S. et al. Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells...
Here we discuss recent advances in understanding the function, the targeting and regulation of IRG and GBP proteins during microbial infections.doi:10.1111/cmi.12546Meunier, EtienneBroz, PetrJohn Wiley & Sons, LtdCellular MicrobiologyMeunier, E. & Broz, P. Interferon-inducible GTPases in cell ...
This study adds a second major function for TRIM5 in innate immune signalling cascades following retroviral infection. Article CAS PubMed PubMed Central Google Scholar Gao, B., Duan, Z., Xu, W. & Xiong, S. Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core ...
function as a receptor for measles virus by binding to its hemagglutinin (MV-H) [29,30,31]. However, it is less known for its antiviral activities and mechanisms. In this study, we characterized PVRL4 as an antiviral ISG that can effectively restrict the infection of multiple enveloped ...
Hemorrhagic shock increases the susceptibility to infection in both clinical and laboratory settings. Hemorrhagic shock also is associated with a decreased production of interferon-γ (IFN-γ), a potent modulator of immune function. We investigated the effect of IFN-γ both alone and in addition to...
Multiple defects of immune cell function in mice with disrupted interferon-gamma genes Science, 259 (1993), pp. 1739-1742 Google Scholar 11 J.E Darnell Jr. STATs and gene regulation Science, 277 (1997), pp. 1630-1635 Google Scholar 12 J.E Darnell Jr., I.M Kerr, G.R Stark Jak-STAT...
The typical manifestation of ACR during antiviral therapy is a secondary increase of liver function test, in particular the transaminases, after an initial improvement or normalization with treatment. This is, however, non-specific and the diagnosis requires a liver biopsy (Fig. 1). In 1997, The...