Description: The DATK32 monoclonal antibody binds to a combinatorial epitope of mouse LPAM-1 (alpha 4/ beta 7), which is a heterodimer of the the 154 kDa alpha 4 subunit and the 130 kDa beta 7 subunit. In mouse, the beta 7 subunit is found on the majority ...
The integrin alpha 4 beta 1 (VLA-4) is a versatile cell-cell and cell-extracellular matrix adhesion receptor. The alpha 4 subunit can be expressed on the cell surface in two forms: an intact form (alpha 4/150) and a cleaved form (alpha 4/80,70). Here we have characterized a third...
In addition to neural crest cells, the integrin α 4 subunit was later observed on the muscle masses of the limb, the apical ectodermal ridge, and the developing liver. To examine the functional role of the integrin α 4 subunit in neural crest cell migration, we used an explant preparation...
Naïve MSCs were shown to express integrin β1subunit (ITGB-1) but do not express the integrin α4(ITGA4) subunit which is required to produce the complete VLA-4 heterodimer33. Previously, it was shown thatitga4gene overexpression in MSCs using viral vector led to proper routing of the ...
Fluorescence-activated cell sorter analysis and immunoprecipitation with monoclonal antibodies demonstrated that normal dermal fibroblasts express the α4-subunit on the cell surface, primarily in association with the β1-subunit. Cell-attachment assays demonstrated that normal human fibroblasts can attach ...
(talin and kindlin) are activated and bind to the cytoplasmic tail of the β-subunit [4]. Activated integrins form strong ligand binding with ECM and continuously recruit clusters. This process is termed “inside-out” signaling of integrin activation. After large amounts of integrins are ...
Alpha subunit of the human beta-2 integrins DNA encoding a novel human beta 2 integrin alpha subunit polypeptide, designated alpha d, is disclosed along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for alpha d are... M Gallatin,M Vi...
(complement component 3 receptor 3 subunit); Integrin, alpha X (antigen CD11C (p150), alpha polypeptide); Integrin, alpha X (complement component 3 receptor 4 subunit); ITGAM; ITGAX; Leu M5, alpha subunit; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor MO1; ...
A minor portion of type II expressed the alpha 4 (CD49d) subunit of the beta 1-integrins, and the alpha-v (CD51) subunit of the receptor. CD11a, CD11b, CD11c, , CD49b, and CD49f failed to demonstrate any immunostaining with type II . In conclusion, the observation of the ...
Psoriasin (S100A7) associates with integrin |[beta]|6 subunit and is required for |[alpha]|v|[beta]|6-dependent carcinoma cell invasion 来自 dx.doi.org 喜欢 0 阅读量: 36 作者:MR Morgan,M Jazayeri,AG Ramsay,GJ Thomas,MJ Boulanger,IR Hart,JF Marshall ...