The integrin alpha 4 beta 1 (VLA-4) is a versatile cell-cell and cell-extracellular matrix adhesion receptor. The alpha 4 subunit can be expressed on the cell surface in two forms: an intact form (alpha 4/150) and a cleaved form (alpha 4/80,70). Here we have characterized a third...
We have previously described the direct interaction of the signaling adaptor molecule paxillin with the cytoplasmic domain of the alpha4 integrin subunit. This interaction is critical for alpha4beta1 integrin dependent cell adhesion under shear flow conditions as it provides a needed connection to the...
Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell. 1993;74(1):185–95. https://doi.org/10.1016/0092-8674(93)90305-a. Article CAS PubMed Google Scholar Hemler ME, Huang C, Schwarz L. The VLA protein family. Characterization of five ...
Thermo MA121434 INTEGRIN ALPHA Thermo MA121434 INTEGRIN ALPHA Thermo PA537758 P53 PSER315 100 UL ￥4,057.00 100 UL Thermo PA537759 P53 PSER33 100 UL ￥4,057.00 100 UL Thermo PA537760 P53 PSER6 100 UL ￥4,057.00 100 UL Thermo PA537761 P53 PTHR387 100 UL ￥4,057.00 100 UL Thermo...
Naïve MSCs were shown to express integrin β1subunit (ITGB-1) but do not express the integrin α4(ITGA4) subunit which is required to produce the complete VLA-4 heterodimer33. Previously, it was shown thatitga4gene overexpression in MSCs using viral vector led to proper routing of the ...
(1994) Activation of the alpha 4 beta 1 integrin through the beta 1 subunit induces recognition of the RGDS sequence in fibronectin. J. Cell Biol. 126, 271-279Sanchez-Aparicio P, Dominguez-Jimenez C, Garcia-Pardo A. Activa- tion of the alpha 4 beta 1 integrin through the beta 1 ...
(talin and kindlin) are activated and bind to the cytoplasmic tail of the β-subunit [4]. Activated integrins form strong ligand binding with ECM and continuously recruit clusters. This process is termed “inside-out” signaling of integrin activation. After large amounts of integrins are ...
(complement component 3 receptor 3 subunit); Integrin, alpha X (antigen CD11C (p150), alpha polypeptide); Integrin, alpha X (complement component 3 receptor 4 subunit); ITGAM; ITGAX; Leu M5, alpha subunit; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor MO1; ...
细胞外段可以和和大部分的细胞外基质(ECM)结合，包括纤连蛋白（FN）、玻连蛋白、胶原和层连蛋白等，也可以和细胞的VCAM和ICAM等细胞表面受体结合,而细胞内段和细胞骨架蛋白连接4, 5。因此，整合素有两个主要的功能：首先，整合素在细胞骨架和细胞外基质之间起到了物理支架的作用，有利于维持组织的正常形态和功能；...
蛋白别名:alpha v integrin; CD51; CD61; GP3A; GPIIIa; Integrin alpha-V; ITGB3; vitronectin receptor alpha polypeptide (VNRA); Vitronectin receptor subunit alpha; VNR 基因别名:1110004F14Rik; 2610028E01Rik; CD51; D430040G12Rik; Itgav ...