Integrin beta-like 1 overexpression stimulates invasiveness of ovarian cancer cells in vitrogrowth was assessed by inoculating cancer cells into the back of BALB/c nude mice. TBOPP, a selective inhibitor of DOCK1 that binds to the catalytic domain of DOCK1 and blocks its GEF activity, was ...
ILK (beta1-integrin-linked protein kinase) is a recently identified 59-kDa serine/threonine protein kinase that interacts with the cytoplasmic domain of the beta1-integrin containing four ankyrin-like repeats. We have developed a polyclonal antibody against ILK and explored the ILK immunoreactivity in...
Objective:This study was intended to modify the surface of a novel near β titanium alloy Ti-5Zr-3Sn-5Mo-15Nb (TLM) by micro-arc oxidation(MAO),and evaluate the influence of MAO process on the morphology and integrin β1(Itgβ1) expression of osteoblasts cultured on TLM. Method:MAO of...
The influence of surface roughness of titanium on beta1- and beta3-integrin adhesion and the organization of fibronectin in human osteoblastic cells. The influence of surface roughness of titanium on β 1- and β 3-integrin adhesion and the organization of fibronectin in human osteoblastic cells[...
SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration. Signal regulatory proteins (SIRPs) comprise a family of cell surface signaling receptors differentially expressed in leukocytes and the central nervous sys... Y Liu,I Soto,...
We next determined the structure of α6β1 headpiece in complex with its ligand LM511 by a cryo-EM approach. As for the LM511, we utilized the E8-like truncated LM511 (tLM511) design reported previously12. In order to maximize the stability of the complex as well as its conformational ...
别名Integrin alpha-L; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; Lymphocyte antigen 15; Ly-15; CD11 antigen-like family member A; CD_antigen; CD11a; ITAL_HUMAN. 浓度1mg/1ml ...
Inhibition of alpha 4 beta 1 function by RGD... The alternatively spliced type III connecting segment (IIICS) region of fibronectin contains two distinct sites that support the adhesion of melanoma cells... AP Mould,A Komoriya,KM Yamada,... - 《Journal of Biological Chemistry》 被引量: ...
N-glycosylation of the I-like domain of beta1 integrin is essential for beta1 integrin expression and biological function: identification of the minimal N-... 1 integrin is essential for beta1 integrin expression and biological function: identification of the minimal N-glycosylation require- ment ...
Collagen-binding integrins refer to a class of integrins that bind with GFOGER-like sequences in collagen, including α1β1, α2β1, α10β1, and α11β1100 (Fig. 3). Integrin α1β1 was first identified in activated T cells.101 It is also expressed in connective tissue cells (such...