Here we show that conditional loss of the TGF-beta-activating integrin alpha(v)beta8 on leukocytes causes severe inflammatory bowel disease and age-related autoimmunity in mice. This autoimmune phenotype is largely due to lack of alpha(v)beta8 on dendritic cells, as mice lacking alpha(v)beta8...
Conversely, some integrin subtypes were inhibitors of OCs differentiation. An animal study showed that integrin αvβ5gene deletion significantly increased the number of OCs in bone tissue, both wild-type and OVX mice [74]. Exogenous supplementation of irisin (skeletal muscle-secreted myokine) was ...
Conditional beta1-integrin-deficient mice display impaired pancreatic beta cell function. J. Pathol. 224(1): 45-55; 2011... Z Wang,Q Xu,F Cai,... - 《Jci Insight》 被引量: 0发表: 2019年 Conditional beta1-integrin-deficient mice display impaired pancreatic beta cell function. Conditio...
are critical for the optimal induction of RV-specific IgA responses in the mesenteric lymph nodes. This depends on the selective expression of the TGFβ-activating integrin αvβ8 by cDC1. In contrast, αvβ8 on cDC1 is dispensible for steady state immune homeostasis. Given that cDC2 are ...
When the HFs entered the subsequent anagen phase at P30, control mice showed b-galactosidase-positive Lgr5 progeny in the isthmus and bulge regions as well as in the non-permanent part of the HF, including a subset of the hair matrix cells (Fig. 3b,c). Strikingly, the frequency of b-...
Epithelial–mesenchymal transition (EMT) plays a pivotal role for tumor progression. Recent studies have revealed the existence of distinct intermediate states in EMT (partial EMT); however, the mechanisms underlying partial EMT are not fully understood.
To analyze the transcriptional activity of the gene encoding the alpha subunit of the platelet integrin alpha(IIb)beta(3) during the hematopoietic differentiation, mice were produced in which the herpes virus thymidine kinase (tk) was introduced in this megakaryocytic specific locus using homologous re...
Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice J. Cell Sci., 122 (2009), pp. 227-232 CrossrefView in ScopusGoogle Scholar Annes et al., 2003 J.P. Annes, J.S. Munger, D.B. Rifkin Making sense of laten...
Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone marrow niche. Here, we demonstrate that Periostin (Postn) via interaction with Integrin-αv (Itgav) regulates HSC proliferation. Systemic deletion of Postn results
Alpha2beta1 and alphaVbeta1 integrin signaling pathways mediate amyloid-beta-induced neurotoxicity. Neurobiol Aging 2007; 28: 226–237. 22. Wang Q, Klyubin I, Wright S, Griswold-Prenner I, Rowan MJ, Anwyl R. Alpha v integrins mediate beta-amyloid induced inhibition of long-term potentiation...