The anti-integrin antibody OPG2 binds in an RGD-related manner to the αIIbβ3integrin as a molecular mimic of fibrinogen. The Fab fragment from OPG2 was cocrystallized with a peptide from the β3subunit of the integrin representing a site that binds RGD. The crystal structure of the ...
including classic Piezo and transient receptor potential vanilloid (TRPV) channels [88,89,90,91]. Osteocytes, OBs, and MSCs in the lacunar-canalicular system are the main cells for the transduction of mechanical and physical stimuli. The morphological structure and volume of mouse cranial ...
We have determined the high resolution crystal structure of the I domain from the α-subunit of the integrinα2β1, a cell surface adhesion receptor for collagen and the human pathogen echovirus-1. The domain, as expected, adopts the dinucleotide-binding fold, and contains a metal ion-...
To gain structural insights into the laminin-integrin interaction, we first determined the crystal structure of ligand binding fragment of human α6β1 (α6β1 headpiece, Fig.1b). Crystallization was facilitated by complex formation with an anti-β1 antibody TS2/16, in a hyper-crystallizable ...
Fig. 5: Interaction between TLN1 and KIND2 is required for integrin functions.a, Binding of the β1-integrin-activation-reporting 9EG7 antibody in the presence of magnesium (white bars) or manganese (patterned bars) normalized to total β1...
2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. Cell 84, 155–164 (1996). Article CAS PubMed Google Scholar Mitjans, F. et al. An anti-αv-integrin antibody that blocks integrin function inhibits the development of a ...
The structure of the C-terminal region is unknown. We have used monoclonal antibodies (mAbs) as probes to study the dependence of the structure of different regions of the αM subunit on association with the β2 subunit in the αM/β2 heterodimer. All of the mAbs to the I-domain ...
Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. We report the 1.8-A crystal structure of the CD11a I-domain with bound manganese ion. The CD11a I-domain contains binding sites for intercellular adhesion ... Qu,D J,Leahy - 《Proceedings of th...
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We have determined the crystal structure of a complex between the I domain of integrin α2β1 and a triple helical collagen peptide containing a critical GFOGER motif. Three loops on the upper surface of the I domain that coordinate a metal ion also engage the collagen, with a collagen glu...