Anti β 2 integrin monoclonal antibodies hold a great potential for preventing inflammation-mediated tissue injuries in several pathological conditions. We have studied the production by a hybridoma cell line of monoclonal 107, an antibody that blocks the function of the...
The AK-7 monoclonal antibody specifically binds to CD49b. CD49b is also known as integrin α2 chain, VLA-α2, and GP1a. CD49b is a type I transmembrane glycoprotein and belongs to the integrin family o
and its inhibitors are recommended for early intervention [116]. Cancer cells with high expression of integrin β3exhibited metabolic abnormalities, including enhanced oxygen consumption, reactive oxygen species, and protein production [117]. mTORC1 is a key target of integrin...
Original article: The role of α2β1 integrin in anchorage dependent apoptosis of breast carcinoma and hepatoma cells The role of collagen specific α2β1 integrin in anchorage dependent apoptosis (anoikis) was investigated. Stimulation of α2β1 signaling with immobilized anti-α2 antibody markedly...
The results of the present study show that beta2-integrin deficiency leads to delayedand severely impaired immune responsiveness in vivo. The observations that antibody production, although considerably delayed and impaired, does occur and that apparently class-switching takes place in BLAD indicate T-...
CD11B/Integrin Alpha M Polyclonal Antibody for WB, IHC, IF/ICC, ELISA Host / Isotype Rabbit / IgG Reactivity humanand More (2) Applications WB, IHC, IF/ICC, ELISA Conjugate Unconjugated Publications 36 Review Product Cat no :21851-1-AP ...
1C). Similarly, both leukadherin and the integrin α2β1 stabilizing antibody increased the amount of αSMA+ collagen I+ double positive cells, while α-α3 did not reduce the number of αSMA+ collagen I+ double positive cells (Fig. 1C). In a companion study, we showed that adhesion...
1d), tlnM3 dramatically increased integrin-αIIbβ3 binding to PAC-1—a well-known ligand-mimetic multivalent antibody that recognizes activated αIIbβ347 compared with either talin-H alone (Fig. 1e) or full-length WT talin (Supplementary Fig. 1f). Because expression of talin-R alone had...
Cells were collected by centrifugation, exposed to a saturating concentration of monoclonal antibody against α2 integrin (12F1) (Pischel et al., 1987) in PBS/bovine serum albumin (1 mg/ml) containing NaN3 at +4°C for 30 min, and stained with rabbit anti-mouse IgG coupled to fluorescein...
β1 integrin, the ApoE2, and the VLDLR are detected in the retained fraction from the Reelin complexed beads but not the control beads. (C) Myc-tagged Reelin secured to sepharose beads with the 9E10 anti-Myc antibody also immunoprecipitates β1 integrin, whereas control beads, in this case...