1. 原位增殖是肿瘤发展的前提,Integrin可以通过偶联蛋白与生长因子受体(EGFR)相互作用激活生长因子(EGF)信号通路并促进原位肿瘤细胞的增殖。 2. 血管生成是肿瘤生长、浸润和转移的重要基础。血管不仅为肿瘤的生长提供必要的营养物质和氧气,也为肿瘤细胞离开原发病灶进入血液提供了有效通道。研究发现Integrin αvβ3会在...
1. 原位增殖是肿瘤发展的前提,Integrin可以通过偶联蛋白与生长因子受体(EGFR)相互作用激活生长因子(EGF)信号通路并促进原位肿瘤细胞的增殖。 2. 血管生成是肿瘤生长、浸润和转移的重要基础。血管不仅为肿瘤的生长提供必要的营养物质和氧气,也为肿瘤细胞离开原发病灶进入血液提供了有效通道。研究发现Integrin αvβ3会在...
889, generating a disulfide-linked, heteromeric subunit Integrin alpha 5 chain. Integrin alpha 5-containing integrins bind multiple ECM molecules, including Vitronectin, Osteopontin, MMP-2, and TSP. The ECD of human Integrin alpha 5 shares 92% aa sequence identity with mouse Integrin alpha 5 ECD...
Integrin α2 is responsible for adhe- sion of platelets and other cells to collagens, modulation of collagen andcollagenase gene expression, force generation and organization of newlysynthesized extracellular matrix.SantosoKalbWalkaKiefelMueller-Eckhardt...
The antibody binds to human (alpha)5(beta)1 integrin with a Kd of 0.367 nM (determined by Biacore), an EC50 of 0.2 nM and an IC50 of 2.3 nM. Clonality Monoclonal Host Rabbit Isotype IgG Kappa Applications Application Recommended Usage Block/Neutralize Optimal dilutions ...
COX-2 inhibitors suppress integrin alpha 5 gene expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites (Retraction of vol 116, pg 536, 2005) Roman,Jesse,Han,... - International Journal of Cancer =: Journal International du Cancer 被引量: 0发...
Proper storage of excessive dietary fat into subcutaneous adipose tissue (SAT) prevents ectopic lipid deposition-induced insulin resistance, yet the underlying mechanism remains unclear. Here, we identify angiopoietin-2 (Angpt2)–integrin α5β1 signalin
We then verified that the interaction between LN-5γ2 and integrin β1 promotes the TB of CRC via the activation of FAK and Yes-associated proteins (YAP). A natural drug monomer, cucurbitacin B, was screened using virtual screening methods for the interaction interface of proteins. We found ...
Neuropilin-2 (NRP2) is a widely expressed membrane-bound multifunctional non-tyrosine kinase receptor, which has previously been implicated in influencing cell adhesion and migration by interacting with α5-integrin and regulating adhesion turnover. α5-integrin, and its ECM ligand fibronectin (FN) ...
Integrin alpha 5 beta 1 controls invasion of human breast carcinoma cells by direct and indirect modulation of MMP-2 collagenase activity. Cell Cycle. 2009; 8 (14):2219–2225. doi: 10.4161/cc.8.14.8980. [ Cross Ref ]Morozevich GE, Kozlova NI, Cheglakov IB, Ushakova NA, Berman AE. ...