ISR是细胞在各种压力刺激下做出的自救反应，这种压力包括：内环境稳态的破坏（代谢紊乱：蛋白稳态，氨基酸...
The integrated stress response (ISR) is a eukaryotic translation initiation factor-2 (eIF2a) phosphorylation-dependent, stress inducible pathway activated by a variety of environmental stresses such as oxidative stress and endoplasmic reticulum stress. However IRS has not been characterized in osmotic ...
The integrated stress response (ISR) is a cytoprotective pathway initiated upon phosphorylation of the eukaryotic translation initiation factor 2 (eIF2α) residue designated serine-51, which is critical for translational control in response to various stress conditions. Four eIF2α kinases, namely heme...
The integrated stress response (ISR) is a cellular signaling network that combines the detection of cellular stresses with the inhibition of translation. From: Advances in Protein Chemistry and Structural Biology, 2022 About this pageAdd to MendeleySet alert ...
Fig. 1: The integrated stress response. During the integrated stress response (ISR), four upstream eIF2α kinases are elicited by different stresses. PERK is primarily activated by the accumulation of unfolded proteins in the endoplasmic reticulum (ER). PKR senses double-stranded RNAs (dsRNAs). ...
Our results also show that senescent cells are further resistant to ISR activation in response to acute proteotoxic, oxidative, and starvation stressors, which all elicit robust expression of ATF4 and an adaptive response in non-senescent cells. Instead, we find that stress induces a transcriptional...
Healthy aging requires the coordination of numerous stress signaling pathways that converge on the protein homeostasis network. The integrated stress response (ISR) is activated by diverse stimuli, leading to phosphorylation of the eukaryotic translation initiation factor eIF2 in its α-subunit. Under re...
ISR: integrated stress response ISRIB: integrated stress response inhibitor PD: Parkinson’s disease PERK: a PKR-like endoplasmic reticulum (ER) kinase PKR: protein kinase R ROS: reactive oxygen species SG: stress granules TC: ternary complex uORF: upstream open reading frame UPR: ...
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α) by one of four...
The integrated stress response (ISR) allows cells to rapidly shutdown most of their protein synthesis in response to protein misfolding, amino acid deficiency, or virus infection. These stresses trigger the phosphorylation of the translation initiation factor eIF2alpha, which prevents the initiation of...