整合应激反应是一种细胞应答机制，用于应对各种不利刺激，包括营养缺乏、氧气不足、感染、化疗等。该反应...
integrated stress response inhibitor PD: Parkinson’s disease PERK: a PKR-like endoplasmic reticulum (ER) kinase PKR: protein kinase R ROS: reactive oxygen species SG: stress granules TC: ternary complex uORF: upstream open reading frame UPR: unfolded protein response UTR: untranslated...
网络整合应激反应 网络释义 1. 整合应激反应 整合应激反应,integrated stress... ... )integrated stress response整合应激反应) integrating remark 整合反应 ... www.dictall.com|基于 1 个网页
The integrated stress response (ISR) is a cellular signaling network that combines the detection of cellular stresses with the inhibition of translation. From: Advances in Protein Chemistry and Structural Biology, 2022 About this pageAdd to MendeleySet alert ...
Impairment of heme production activates the integrated stress response, allowing bypass of inhibitory upstream open reading frames in the PD-L1 5′ untranslated region, resulting in enhanced PD-L1 translation and suppression of anti-tumor immunity. We demonstrate that integrated stress-response-dependent...
integrated stress response ISR proteomics ribosome sequencing nanopore direct RNA sequencing senescence-associated secretory phenotype SASP Introduction Cellular senescence is a state of indefinite cell-cycle arrest that typically occurs in response to sublethal genomic damage. Senescence is expected to primarily...
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α) by one of four...
Healthy aging requires the coordination of numerous stress signaling pathways that converge on the protein homeostasis network. The integrated stress response (ISR) is activated by diverse stimuli, leading to phosphorylation of the eukaryotic translation initiation factor eIF2 in its α-subunit. Under re...
Using multiple individual KC corneas, we determined that matrix production by keratocytes is severely impeded due to an altered stress response program. KC and donor (DN) stromal keratocytes were cultured in low glucose serum-free medium containing insulin, selenium and transferrin. Fibronectin, ...
integrated stress response human hematopoietic stem cells leukemia stem cells Keywords amino acid deprivation Introduction Replenishment of the blood system throughout the lifetime of an organism requires longevity and integrity of the stem cell pool. However, human HSCs are sensitive to perturbations of...