Signal transduction pathways leading to insulin-induced early gene induction. We examined the signal transduction pathway leading to insulin stimulation of two immediate early genes, c-fos, and the early growth response gene, Egr-1. ... BH Jhun,T Haruta,JL Meinkoth,... - 《Biochemistry》 被...
However, the effect of insulin on the parallel p38 pathway is less well understood. The present work examines the effect of inhibiting the p38 signaling pathway by use of specific inhibitors, either alone or in combination with insulin, on the activation of ERK1/2 and on the regulation of ...
3) Insulin signal transduction pathway 胰岛素信号传导通路 1. Part 1 Effects of fibrillar Aβ_((1-40)) on the growth and theInsulin signal transduction pathwayrelated protein of cultured primitive rat basal forebrain cholinergic neuronsObjective1. ...
13.The Effect of Insulin Postreceptor Signal Pathway in Pathogenesis of Gestational Diabetes Mellitus胰岛素受体后信号通路与妊娠期糖尿病发病机制的研究 14.Progress in signal transduction of glucagon-like peptide 1 on regulating insulin-secreting cell mass and function胰高血糖素样肽1类似物调节胰岛素分泌细胞...
Kim YB, Nakajima R, Matsuo T et al. (1996) Gene expres- sion of insulin signal-transduction pathway intermediates is lower in rats fed a beef tallow diet than in rats fed a saf- flower oil diet. Metabolism 45:1080-1088Gene expression of insulin signal-transduction pathway intermediates is ...
Insulin resistance is an important pathogenesis of type 2 diabetes mellitus, it plays a role in the whole process of its development. This article briefly summarizes the insulin signal transduction pathway, and cell level, molecular transduction level and metabolite level of insulin resistance....
Insulin is a protein hormone that controls the metabolism of sugar, fat and protein via signal transduction in cells, influencing growth and developmental processes such as reproduction and ageing. From nematodes to fruit flies, rodents and other animals
The insulin growth factor signal transduction pathway is an important regulator of adult hepatocyte proliferation. The purpose of this study was to determine the roles of the insulin receptor substrate (IRS-1 and IRS-2)-mediated growth cascades in rapidly growing fetal rat liver. We determined the...
3K and so on,have become hot issues of the study on the molecular mechanism of insulin resistance.This paper is to review current literature on these topics. 关键词: signal transduction receptors insulin insulin resistance diabetes mellitus review literature 被引量: 7 年份: 2003 ...
Insulin signaling controls cell growth and metabolic homeostasis. Dysregulation of this pathway causes metabolic diseases such as diabetes. Insulin signaling pathways have been extensively studied. Upon insulin binding, the insulin receptor (IR) triggers