The meaning of INSULIN RESISTANCE is reduced sensitivity to insulin by the body's insulin-dependent processes (such as glucose uptake and lipolysis) that is typical of type 2 diabetes but often occurs in the absence of diabetes.
Prepubertal boys with PA show differences in the IGF system and decreased insulin sensitivity, independent of obesity, as observed in girls with PA. These findings suggest that both boys and girls with PA should be monitored for the development of insulin resistance and associated complications, ...
Prepubertal boys with PA show differences in the IGF system and decreased insulin sensitivity, independent of obesity, as observed in girls with PA. These findings suggest that both boys and girls with PA should be monitored for the development of insulin resistance and associated complications, ...
W KiessJ DötschT SieblerJohn Wiley & Sons, Ltd.European Journal of Clinical InvestigationKiess W, DoE tsch J, Siebler T (1997) Decreased sensitivity to insulin-like growth factor I as a cause of growth failure in Turner's syndrome? Eur J Clin Invest 27:548±549...
Turner's syndrome is characterized, amongst other things, by growth retardation with high serum levels of insulin-like growth factor 1 (IGF-I) in relation to growth, by a tendency to autoimmune disease and by insulin resistance with hyperlipidaemia. Assuming a role for IGF-I subresponsiveness in...
Moreover, such systems release insulin irreversibly, meaning that, once the insulin is released from the depot, it is no longer glucose sensitive. A better approach seems to be equipping insulin itself with glucose-responsive properties, so it can respond to glucose in a reversible manner. ...
[289,290]. Moreover, it has been recently proven that IGF-1 central administration also induced improvement in insulin sensitivity [291], meaning that this sudden rise after exercise or treatment could be of benefit not only in the periphery, but acting centrally. It must be reminded that in...
(RNA-seq) to identify genes whose expression in the placenta was associated with insulin sensitivity in pregnancy. We identified the insulin-like growth factor binding protein 1 gene (IGFBP1) as the most strongly associated placental transcript. IGFBP1 is a binding protein that is produced ...
Metabolic and therapeutic effects of insulin-like growth factor I. The administration of rhIGF-I in appropriate doses leads to a decrease of insulin and growth hormone secretion and to an increase of insulin sensitivity. I... ER Froesch,PD Zenobi,M Hussain - 《Hormone Research in Paediatrics...
[289,290]. Moreover, it has been recently proven that IGF-1 central administration also induced improvement in insulin sensitivity [291], meaning that this sudden rise after exercise or treatment could be of benefit not only in the periphery, but acting centrally. It must be reminded that in...