Height and body mass index (BMI) was calculated from the height and weight data with the formula: BMI = weight (kg)/height squared (m2)20. Blood pressure data were measured several times and averaged. Statistical analysis NHANES adopts complex and multi-stage probabilistic sampling design ...
Reduced insulin sensitivity (insulin resistance) is a hallmark of normal physiology in late pregnancy and also underlies gestational diabetes mellitus (GDM). We conducted transcriptomic profiling of 434 human placentas and identified a positive association between insulin-like growth factor binding protein ...
An apparatus and method are provided for determining a patient's carbohydrate to insulin ratio (CIR) and insulin sensitivity factor (ISF), and using these values, along with values for current blood glucose level and deviation from target blood glucose level, for determining insulin dose in view...
Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulatorsIGF1R biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator, wherein the method ...
“Urinary C-peptideexcretion andHOMAindices [HOMA1-IR formula] decreased significantly, whereas whole-body insulin sensitivity, measured using the hyperinsulinaemic euglycaemic clamp technique, was not significantly changed.” See footnote labelled PPS at bottom page for confusing details. ...
Insulin resistance index determined by HOMA IR was computed according to the following formula (24): HOMA-IR=Fasting Plasma Insulin Level(mIU/L)×Fasting Plasma Glucose Level(mmol/L)/22.5 Gonadotropin Stimulation for IVF, Oocyte Retrieval, and Samples Collection All of our patients were given 400...
Moreover, novel data from human myotubes revealed a negative association between FNDC5 expression and appropriately adjusted in vivo measures of insulin sensitivity in young donors. This finding was replicated in myotubes from elderly men. Conclusions/interpretation This study provides evidence that the ...
C-reactive protein (CRP) and liver function tests (ALT, AST and GGT), as well as the full hematological profile (red blood cells, hematocrit and leukocyte formula) were determined. HbA1c was measured by ion-exchange high performance liquid chromatography on a VARIANT II Turbo Instrument (Glyco...
Mechanistically, WDR6 interacts with the beta-type catalytic subunit of serine/threonine-protein phosphatase 1 (PPP1CB) to facilitate PPP1CB dephosphorylation at Thr316, which subsequently enhances fatty acid synthases transcription through DNA-dependent protein kinase and upstream stimulatory factor 1. ...
The t1/2 values, which define the residence time, were determined using the formula ln2/koff. To compare the binding of NR-7 structures between IR and IGF1R, ECD-IR and ECD-IGF1R proteins (Nordic BioSite) were immobilized on two different flow cells of a CM5 sensor chips via amine ...