Lab Studies Routine laboratory measurements in the evaluation of patients with insulin resistance syndrome include the following: Plasma glucose level (fasting, random, and oral glucose tolerance test) - Diagnosis and monitoring of glucose intolerance (diabetes mellitus, impaired glucose tolerance [IGT],...
insulin resistance; T3DM; mTOR; ER stress; autophagy; inflammation 1. Introduction Diabetes is a metabolic disease that is characterized by the appearance of chronic hyperglycemia because of pancreatic β cell failure by different mechanisms. This decline of β cells occurs in all types of diabetes...
But if you have insulin resistance, this process doesn't work well. Your cells aren't letting glucose in when insulin "asks" them to. As a result, more and more blood glucose piles up in your bloodstream. And your pancreas keeps making insulin. For a while, your pancreas may be able ...
Animal work described in this manuscript has been approved and conducted under the oversight of the Columbia University Institutional Animal Care and Use Committee. Mice (C57BL/6 J, stock #000664, Jackson laboratory) were fed a standard rodent chow (Lab diet, #5053). All animals were mainta...
Duckworth WC 1997 Tumor necrosis factor and insulin resistance: Specificity of sequence accounts of inhibition of insulin action, J Lab Clin Med 130(2):139-146.Tumor necrosis factor and insulin resistance: specificity of sequence accounts of inhibition of insulin action - WC - 1997 () Citation ...
Insulin resistance is a critical process in the initiation and progression of diabetic nephropathy (DN). Alprostadil (Prostaglandin E1, PGE1) had protective effects on renal function. However, it is unknown whether PGE1 inhibited insulin resistance in renal tubule epithelial cells via autophagy, which...
Traumatic brain injury (TBI) is a risk factor for Alzheimer’s disease (AD), although the mechanisms contributing to this increased risk are unknown. Insulin resistance is an additional risk factor for AD whereby decreased insulin signaling increases syn
Reducing insulin/IGF signaling allows for organismal survival during periods of inhospitable conditions by regulating the diapause state, whereby the organism stockpiles lipids, reduces fertility, increases stress resistance, and has an increased lifespan. The Target of Rapamycin (TOR) responds to changes...
It is probably an important signal molecule linking obesity and insulin, and it is associated with the occurrence of insulin resistance. Therefore, it may be associated with the occurrence and development of vascular diseases. Many factors can influence the expression levels of resistin. 关键词: ...
To promote the stability and bioavailability of DNA nanostructures in vivo, insulin NanoRods were coated with oligolysine-PEG (K-PEG), which increases the resistance to nuclease digestion29,30. We confirmed that coated NR-7 (NR-7K-PEG) was able to bind ECD-IR by SPR, but with lower ...