Insulin resistance is when cells in your muscles, fat, and liver don’t respond well to insulin, a hormone made by your pancreas that helps manage your blood glucose (blood sugar). Sometimes, insulin resistance is a short-term condition. But if left untreated for a long time, it could tu...
Lab Studies Routine laboratory measurements in the evaluation of patients with insulin resistance syndrome include the following: Plasma glucose level (fasting, random, and oral glucose tolerance test) - Diagnosis and monitoring of glucose intolerance (diabetes mellitus, impaired glucose tolerance [IGT],...
Conclusions: We suggest that the OLTT/OGTT insulin output ratio (NIOR) may be predictive for identifying individuals who are phenotypically susceptible to insulin resistance in response to high fat or carbohydrate in their habitual diet. Clin Chem Lab Med 2007;45:1124–32. 展开 ...
Low-grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Studydoi:10.1111/PEDI.12607Cesar A Agostinis-SobrinhoRobinson Ramirez-VelezAntonio Garcia-HermosoCarla MoreiraLuis Carlos Oliveira Lopes...
& Choi, E. Insulin receptor endocytosis in the pathophysiology of insulin resistance. Exp Mol Med, 52, 911–920 (2020). Park, J. et al. MAD2-dependent insulin receptor endocytosis regulates metabolic homeostasis. Diabetes, 72, 1781–1794 (2023). Najjar, S. M., Caprio, S. & Gastaldell...
Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible humans, underscoring its important role in the complex pathogenesis of this disease. Insulin resistance contributes to multiple tissue defects characteristic of T2D, including reduced insulin-stimulated glucose uptake...
Reduced insulin sensitivity (insulin resistance) is a hallmark of normal physiology in late pregnancy and also underlies gestational diabetes mellitus (GDM). We conducted transcriptomic profiling of 434 human placentas and identified a positive associati
To promote the stability and bioavailability of DNA nanostructures in vivo, insulin NanoRods were coated with oligolysine-PEG (K-PEG), which increases the resistance to nuclease digestion29,30. We confirmed that coated NR-7 (NR-7K-PEG) was able to bind ECD-IR by SPR, but with lower ...
18. ObjectiveTo observe the effect of Yuye Tang on the expression of GLUT-4mRNA in muscle of insulin resistance rats. 目的观察玉液汤对胰岛素抵抗大鼠骨骼肌中葡萄糖转运子-4 mRNA(GLUT-4 mRNA)表达的影响。 19. However, diabetics must still rely on the fingerstick test to decide whether additiona...
Insulin resistance is a critical process in the initiation and progression of diabetic nephropathy (DN). Alprostadil (Prostaglandin E1, PGE1) had protective effects on renal function. However, it is unknown whether PGE1 inhibited insulin resistance in re