Background: Fatty liver disease (FLD) is a common comorbidity of psoriasis and is often referred to as non-alcoholic fatty liver disease (NAFLD). However, the role of inflammation or insulin resistance (IR) in FLD is inconclusive. The study aims to explore whether FLD ...
Hepatic steatosis is a strong predictor of the development of insulin resistance and often precedes the onset of other known mediators of insulin resistance. This sequence of events suggests that hepatic steatosis has a causal role in the development of insulin resistance in other tissues, such as ...
Insulin resistance in humans is not always accompanied by obesity, since severe insulin resistance also characterizes patients lacking subcutaneous fat such as those with HAART- (highly-active antiretroviral therapy)-associated lipodystrophy. Both obese and lipodystrophic patients, however, have an increase...
We also discuss lifestyle strategies for optimising metabolic liver health. Keywords: metabolic-associated fatty liver disease; insulin resistance 1. Introduction Globally, obesity prevalence has tripled over the last 50 years, with obesity and overweight now affecting 650 million and 1.9 billion people...
Conclusion: AET prevented the LS-diet-induced TG accumulation in the liver by improving insulin sensitivity and the expression of insulin-regulated genes and oxidative capacity. Keywords: sodium restriction; aerobic exercise; insulin resistance; dyslipidemia...
Liver disease Increased triglycerides Increased LDL ("bad") cholesterol Heart disease Eye issues Some types of cancer Alzheimer’s disease Insulin resistance weight gain In the short term, high blood sugar levels can cause you to gain weight. Losing those extra pounds can be a challenge because ...
Insulin Resistance Exacerbates Genetic Predisposition to Nonalcoholic Fatty Liver Disease in Individuals Without DiabetesThe accumulation of excess fat in the liver (hepatic steatosis) in the absence of heavy alcohol consumption causes nonalcoholic fatty liver disease (NAFLD), which has become a global ...
It is tempting to conclude that hepatic TG per se may not be responsible for the resistance seen in . The genetic/molecular bases for the differences between SWR/J and the other two strains with respect to their metabolic responses to increases in hepatic TG contents remain to be elucidated....
Ectopic fat accumulation in the liver causes nonalcoholic fatty liver disease (NAFLD), which is the most common cause of chronic liver disease in Western countries. Ectopic liver lipid, particularly diacylglycerol, exacerbates hepatic insulin resistance, promotes systemic inflammation, and increases risk ...
Non-alcoholic fatty liver disease (NAFLD) has been associated with several metabolic conditions (MC) and secondary causes, but the relationship between insulin resistance (IR) and the underlying aetiology of NAFLD has not been extensively explored. To determine the frequency of IR among NAFLD patient...