FATTY LIVER-DISEASECARDIOVASCULAR RISK-FACTORSHEPATIC INSULIN-RESISTANCEBETA-CELL PROLIFERATIONADIPOSE-TISSUEBODY-FATWEIGHT-LOSSIN-VIVOMETABOLIC COMPLICATIONSADIPOCYTE INFLAMMATIONThe accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly ...
Excessive caloric consumption combined with a sedentary lifestyle cause triglycerides to be stored in fat tissue. When you eat less and exercise more, a hormone known as lipase begins breaking down stored fat. Tissues throughout the body, such as the muscle and liver, metabolize the previously s...
Insulin resistance and inflammation are recognized as important links between obesity and cardiovascular disease (CVD). Plasma free fatty acids (FFA), eith... Guenther,Boden,Sajad,... - 《Current Pharmaceutical Design》 被引量: 32发表: 2013年 Does obesity cause type 2 diabetes mellitus (T2DM)?
Nonalcoholic fatty liver disease(NAFLD) including nonalcoholic steatohepatitis(NASH) is globally increasing and has become a world-wide health problem. Chr... Y Haga,T Kanda,R Sasaki,... - 《World Journal of Gastroenterology》 被引量: 46发表: 2015年 A comparison of the fibrotic potential of...
Expression of the Pnpla3 paralog, Pnpla5, was increased in adipose tissue but not in liver of Pnpla3-deficient mice, but compensatory regulation of genes involved in TAG metabolism was not identified. Together these data argue against a role for Pnpla3 loss-of-function in fatty liver ...
“Caffeine in coffee, tea, or soft drinks,” Dr. Lane says, “causes a transient insulin resistance that can produce exaggerated glucose and insulin responses when carbohydrate is consumed.” This seems to me to be the key. It’s really the same old story. “Diabetes,” as Dr. Lane poin...
Understanding Non-Alcoholic Fatty Liver Disease (NAFLD) NAFLDhappens when too much fat builds up in the liver, even if you don’t drink a lot of alcohol. This can causeinflammation, scarring, and evencirrhosis. Cirrhosis is a severe liver disease that can be life-threatening. ...
I now have a small level, but disturbing threat, of fatty liver disease caused from a previous chemotherapy that wrecked havoc on my body. It is critical for me to lose the weight. I am avid exerciser, and a overall healthy eater. I need help beyond the basic… ...
Plasma non-esterified fatty acids were suppressed by the test meal to the same extent following all three diets, indicating a similar insulin-mediated action on inhibiting adipose tissue lipolysis and postprandial increases in GIP and GLP-1 did not differ. No other statistically significant ...
To confirm the LPS–TLR4 role in insulin resistance, recent evidence has revealed that NLRP3 activation represents an essential mechanism in metabolic inflammation and insulin-resistance induction [61], and its inhibition could prevent ischemic stroke in diabetic patients [62]. Furthermore, as ...