Tousch Didier,Lajoix Anne-Dominique,Hosy Eric,et al.Chicoric acid,a new compound able to enhance insulinrelease and glucose uptake. Biochemical and biophys-ical research communications . 2008Tousch D, Lajoix AD, Hosy E, Azay-Milhau J, Ferrare K, Jahannault C, Cros G, Petit P. ...
a得到客户订单 Obtains the customer order form[translate] a一般按默认,一直点“下一步”即可 Presses the default generally, selects continuously “next step” then[translate] ainsulin-stimulated glucose uptake 胰岛素被刺激的葡萄糖举起[translate]
Thus, one may define a threshold concentration for the insulinotropic action of D-glucose (close to 5 mM), a concentration of the hexose yielding a half-maximal secretory response (close to 10 mM), and a maximal velocity of insulin release that is observed at high D-glucose concentrations (...
The rate-limiting step in glucose utilization under all conditions was glucose transport. Even at high insulin concentrations, free glucose was not detected in the muscle cells of young or old rats, the uptake of 2-deoxyglucose diminished in parallel with that of glucose, and there was no ...
A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes. This is due to improved glucose-stimulated acute insulin release and redistribution of substrates with increased glucose uptake in adipose tissue and liver in... F,...
The stimulus secretion coupling of glucose-induced insulin release: Effect of lactate upon islet function In isolated rat pancreatic islets, exogenous l-lactate causes a dose-related enhancement of glucose-induced insulin release and shifts the sigmoidal curve ... Willy J. Malaisse and Shoji Kawazu...
Pharmacological activation of AMPK promotes glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and insulin sensitivity; processes that are reduced in obesity and contribute to the development of insulin resistance. AMPK deficient mouse models have been used to provide direct genetic evidence ...
A simple system has been described in which insulin stimulation of glucose uptake by HeLa cells can be measured after a three hour incubation in a solution of bicarbonate buffered saline. The glucose uptake of HeLa cells in the presence and absence of insulin in the above medium was compared ...
20–35 kDa guanine nucleotide-binding proteins that switch between an inactive GDP-bound conformation and an active GTP-bound conformation. Guanine nucleotide exchange factors (GEFs). A family of enzymes that activate GTPases by catalysing GDP release, thus allowing cytoplasmic GTP to bind to the ...
The most rapid age-related decrease in insulin-stimulated glucose uptake in skeletal muscle occurs between 3 and 5 wk of age in rats. Therefore, we studied unstimulated, insulin-stimulated, and in vitro hypoxia-stimulated 2-deoxy-D-[G-3H]glucose (2-DG) uptake in isolated soleus, flexor digi...