The other way to use rHuPH20 is pre-administration of the enzyme by itself using insulin pumps. The concept is to infuse just a single dose of Hylenex® (an FDA approved formulation of the enzyme alone) when pump patients change infusion sites every two to three days. Halozyme is curre...
A system is disclosed for demand-based administration of insulin which utilizes a change in a physical property of a patient's body fluid as an indicator that a change in the body fluid glucose level has occurred and that an appropriate amount of insulin should be supplied to the patient. Bo...
2. The method of claim 1, wherein said fusion protein inhibits tumor growth in said mammal after said administration. 3. The method of claim 1, wherein said mammal has a reduction in tumor volume of at least 30% after said administration as compared to an untreated control. 4. The metho...
At steady state, the 24-hour glucose lowering effect (GIR-AUC0-24) of TOUJEO 0.4 U/kg was approximately 27% lower with a different distribution profile than that of an equivalent dose of LANTUS [see DOSAGE AND ADMINISTRATION, WARNINGS AND PRECAUTIONS, and Pharmacokinetics]. The glucose lowering...
An increase in blood glucose greater than 1.7 mmol/L (30 mg/dL) within 30 - 40 minutes after IM or IV administration of 1 mg glucagon. Indeed insulin promotes glycogen storage and inhibits its use. Conversely, glucagon stimulates glycogenolysis. When glucagon increases blood glucose, it proves...
In type 1 diabetes patients treated with IV insulin, consider the longer onset of action of TOUJEO before stopping IV insulin. The full glucose lowering effect may not be apparent for at least 5 days [see DOSAGE AND ADMINISTRATION and CLINICAL PHARMACOLOGY]. Hypoglycemia Hypoglycemia is the most...
The mode of administration for the most effective response may need to be determined empirically and the means of administration described below are given as examples, and do not limit the method of delivery of the composition of the present invention in any way. All the above formulations are ...