Insulin is an extensively studied peptide hormone in mammals. However, insulin is not restricted to vertebrates, but has also been identified in invertebrates, among whom several insect species. These insulin-like peptides (ILPs) show structural and鈥攁t least some鈥攆unctional homology with ...
Chapter 38 – Insulin-Like Peptidesdoi:WO2005047316 A2The present invention relates to peptides, or fragments thereof, isolated from the skin secretions of amphibians and which act as stimulators of insulin secretion and pancreatic beta cell function.The invention also encompasses peptide having ...
This chapter discusses the insulin-like peptides: structure, signaling, and function. Insulin-like peptides (ILPs) are paragons for the conservation of hormone structure and function among invertebrates and higher animals. They are encoded by multiple, distinct genes within each species and, upon ...
The role of a new insulin-like peptide in the pearl oyster Pinctada fucata martensiiPeptidesTranscriptional regulatory elementsInsulin signalling, is an economically important marine bivalve species cultured for seawater pearls. At present, we know little about the molecular mechanisms of the insulin ...
INSULIN LIKE PEPTIDESBarlos, KleomenisBarlos, Konstantinos
The insulin/IGF-1 signalling (IIS) pathway plays an important role in the regulation of larval diapause, the long-lived growth arrest state called dauer arrest, in Caenorhabditis elegans. In this nematode, 40 insulin-like peptides (ILPs) have been identi
Honey bees have two insulin-like peptides(Ilps; (Wheeler et al., 2006))which are expressed in fat body but have different spatial patterns (Nilsen et al.,2011).The fat body is a loose tissue analo-gous to vertebrate liver and adipose, and is the primary site of energy storage in in...
Insulin-like/related peptides(ILPs)of invertebrate are homologous of vertebrate insulin. This article rewiewed the structure, expression, signalling pathway of ILPs. The functions of ILPs were also summarized in regulating growth, development, metabolism, reproduction and immunity.关键词: Insects Insul...
胰岛素样蛋白(Insulin-like/relatedpeptides,ILPs)是无脊椎动物中胰岛素的同源基因。以昆虫为例,概述了ILPs的结构、表达以及相关通路特别是胰岛素信号通路(Insulinsignalingpathway),并总结了其在调控机体生长、发育、新陈代谢、繁殖和免疫等生命过程中的作用。 References [1] Nagasawa H, Kataoka H, Isogai A, et ...
Insulin family peptides are known to be key regulators of growth and metabolism in insects and vertebrates. Insects have two types of insulin family peptides: insulin-like peptides and insulin-like growth factor (IGF)-like peptides (IGFLPs). We recently demonstrated that an IGFLP in the silk...