C. elegans oogenesistaste neuronsolfactory neuronsinsulin-like peptidesinsulin signalingfertilizationbacterial food sourcesfood qualityThe environment is widely known to impact organismal reproduction. Thus, a mechanism that allows the animal to sense and adjust to its environment should make fMishra, ShashwatMarbach, KelseyPereira, Bianca...
C. elegans expresses 40 insulin-like peptides, including agonists and antagonists of DAF-2, an insulin/IGF-1 receptor homolog [5]. When a ligand binds to DAF-2, it sets off a series of phosphorylation events that activate different kinases, including AGE-1/PI3K, pyruvate dehydrogenase lipoam...
Neuropeptides and insulin-like peptides were enriched among the upregulated genes in both LRRK2 transgenic and wild-type animals grown on A. viscosus (Sup Table 1). In C. elegans, insulin-like signaling has a negative impact on ageing; loss of DAF-2, the C. elegans insulin-like receptor...
TheC. elegansgenome encodes 154 known neuropeptide genes, 40 genes belong to the insulin-like family of peptides, 31 genes are FMRFamide-related peptides, and 83 genes encode non-insulin, non-FMRFamide-related neuropeptides87. Our analysis shows that 37 neuropeptide genes exhibit dimorphic express...
The C. elegans genome contains 37 genes encoding predicted insulin-like peptides [71]. Transcripts for two of these, ins-1 and ins-18, are enriched; ins-17, ins-24 and ins-30 are present but not significantly elevated relative to other cells. ins-1 and ins-18 have been implicated in...
TheC. elegansgenome encodes 154 known neuropeptide genes, 40 genes belong to the insulin-like family of peptides, 31 genes are FMRFamide-related peptides, and 83 genes encode non-insulin, non-FMRFamide-related neuropeptides87. Our analysis shows that 37 neuropeptide genes exhibit dimorphic express...
The nematode Caenorhabditis elegans exhibits rapid senescence that is promoted by the insulin/IGF-1 signalling (IIS) pathway via regulated processes that are poorly understood. IIS also promotes production of yolk for egg provisioning, which in post-repr
elegans: TGF-β signaling pathway, p38 MAPK signal- ing pathway and insulin receptor-like signaling pathway, which has different roles in resistance to external adverse stimuli, respectively [30–32]. Antimicrobial peptides such as lysozyme genes, ASABF family, sphingolipid- activated protein family...
Age-associated neurodegenerative disorders such as Alzheimer’s disease are a major public health challenge, due to the demographic increase in the proportion of older individuals in society. However, the relatively few currently approved drugs for these
A functional study of all 40 Caenorhabditis elegans insulin-like peptides 2019, Journal of Biological Chemistry Citation Excerpt : For a list of strains and primer sequences please see Tables S6 and S7. Nonstarved well-maintained mixed stage worms were collected to prepare embryos, as described ...