Obesity: is evolution to blame? It aims to understand how excessive caloric intake and the resulting increased fat mass cause insulin resistance and other features of the metabolic syndrome. However, is studying the consequences of obesity the best choice to control the... E Fliers 被引量: 5发...
a"Insulin is important in the body for controlling blood sugar, but it may play a different role in the brain, where insulin appears to disturb memory and learning," Gomez-Pinilla said.[translate]
As far as insulin resistance is concerned, nutrition is a key element of therapy. In terms of the diet of people insulin resistance, it is important that they eat regularly in addition to maintaining the proper the composition and volume of meals [25]. The main dietary recommendations aimed ...
Insulin resistance is when cells in your muscles, fat, and liver don’t respond well to insulin, a hormone made by your pancreas that helps manage your blood glucose (blood sugar). Sometimes, insulin resistance is a short-term condition. But if left untreated for a long time, it could tu...
It also induces cell growth and proliferation [147]. Binding of insulin to its cell surface receptor is essential to mediate its action [148], because this leads to autophosphorylation followed by increased tyrosine kinase activity in the cytoplasmic β subunits of insulin receptors. This increased ...
Insulin resistance in type 1 diabetes is an extremely important clinical aspect because it increases the risk of chronic complications' development. Identification of insulin resistant patient with type 1 diabetes is essential for better metabolic control and prevention of long-term complications in this...
These changes are important, because it has been shown that the products of these insu- lin independent metabolic pathways lead to polyol for- mation and advanced glycation end products, which can contribute to the numerous complications and premature atherosclerosis seen in diabetic patients [58]....
based approach is still of great risk as insulin receptor is one of the most important mechanisms of human beings involved in physiological glucose homeostasis (Chen and Liu, 2012). View chapterExplore book Membranes and Intracellular Signal Transduction...
Insulin signalingis important for insulin action in both classical (liver, muscle and adipose) and unexpected (pancreatic β-cell, brain and vascular endothelium) tissues. • Insulin resistance in diabetes and metabolic syndrome is driven by many extrinsic factors and new cell-intrinsic factors that...
Under normal conditions, insulin promotes hepatic de novo lipogenesis (DNL). However, during insulin resistance (IR), when insulin signalling is blunted and accompanied by hyperinsulinaemia, the promotion of hepatic DNL continues unabated and hepatic ste