It is hoped by these methods to produce medically useful proteins cheaply and on a large scale. In addition, new bacteria with useful properties may be “created” (e.g., bacteria able to convert cellulose to methane for energy production). (At present two different microorganisms must be use...
et al. Obesity and renal disease: not all fat is created equal and not all obesity is harmful to the kidneys. Nephrol. Dial. Transplant 56, 860–872 (2014). Google Scholar Stefan, N. & Haring, H. U. The role of hepatokines in metabolism. Nat. Rev. Endocrinol. 9, 144–152 (20...
Our study demonstrates that S597 activates both the PI3K-AKT and MAPK pathways, and induces IR endocytosis in the liver, similarly to insulin. The liver is the major organ for insulin clearance mediated by IR endocytosis, and defects of this process can cause hyperinsulinemia47,48,49,50. The ...
Feeding rats fructose stimulated FAS, and created a 56% increase in TG secre- tion rate, and an 86% increase in plasma TG. Feeding glu- cose, however, did not have this effect on TG production, nor did it affect induction of FAS. This is likely because glucose stimulates both TG ...
(peer review). If the abovementioned is occurring, it could mean that IGF-1 administration could also lower glucose levels by suppressing hepatic gluconeogenesis, as well as improving insulin signalling in this organ, leading to IGFBP-1 suppression and overall improvement of the IGF-1/GH/insulin...
This created an emphasis on improving the user experience with laboratory technology. Talent retention was viewed as a key performance indicator (KPI) due to limited availability in specific regions. Ignoring the user experience when deploying technology jeopardizes labeffectiveness and efficiency, risking...
humans. While it is known that theIrsgene family originated in vertebrates, it is not known when it originated and which members are most closely related to each other. A better understanding of the evolution ofIrsgenes and proteins should provide insight into the regulation of metabolism by ...
Insulin signaling is initiated by the binding of insulin to the α subunit of the insulin receptor (IRα), which activates the tyrosine kinase activity of β subunit of the insulin receptor (IRβ) by phosphorylating tyrosine residues in the cytoplasmic domain of IRβ2. Insulin signaling proceeds...
Notably, the liver is a key metabolic organ that orchestrates and regulates a plethora of metabolic pathways, including estrogen and insulin signaling33. During spaceflight, the liver RNA-seq data exhibits the most pronounced and unique impact on metabolic pathways as well as insulin and estrogen si...
For each group BAPs are implanted into an omental pouch in the peritoneum using a midline laparotomy incision under general anesthesia (see operative technique below) (N=3) or into a subcutaneous pocket created on the abdominal wall (N=2). No immunosuppression is used. Accucheck glucometers ...