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The goal of targeted delivery is to achieve an optimal concentration of an active agent to maximize exposure of target tissue, while remaining the levels in non-target tissues below the threshold of unacceptable organ toxicity and exposure. The inhibitor of the instant invention may bind and ...
Exosomes are implicated in the processes of tissue and organ development and differentiation. Retinoic acid facilitates the conversion of P19 cells (UD-P19) to P19 neurons (P19N), replicating the features of cortical neurons and expressing characteristic genes, including NMDA receptor subunits. We...
Such images, obtained serially through the whole length/depth for the muscle block, tend to be aligned and stacked for 3D reconstruction. HREM has proven is especially beneficial when integrated in correlative multimodal imaging (CMI) pipelines. CMI creates a composite and zoomable view of the sam...