Some of the findings concerning the relationships between insulin signaling and aging are not easy to reconcile and have been described as paradoxical.1 The purpose of this article is to review evidence that links insulin actions with aging and longevity. Following a very brief synopsis of results...
adult brain and is required for NSC maintenance. In this Review, we discuss emerging data on the functions of IGF-II and IGF and/or insulin receptor signalling in the context of NSC regulation in the SVZ and SGZ. We also propose a model for IGF-II in which the choroid plexus is a maj...
Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling GH/insulin/IGF-1 signaling is a vital pathway e.g. in the regulation of protein synthesis and glucose metabolism. However, mouse dwarf strains which exhibi... A Salminen,K Kai - 《Cellular Signalling》 被引量: ...
elegans 基因组中发现 39 种胰岛素样蛋白, 命名为 INS1-39.INSs 与 insulin/IGF-1 受体 DAF-2 结合,激活并参与胰岛素 / 胰岛素样生长因子信号 (Insulin/insulin-like growth factor 1 signaling,IIS)通路, 调控机体的衰老,寿命及免疫等生命活动[28].在椎 实螺中发现 7 个 ILPs[29],结构同哺乳动物胰岛素...
The data revealed that rosavin activated the insulin/IGF-1 signaling pathway by downregulating the upstream components daf-2 and age-1. In summary, these results verify that rosavin could increase the lifespan of Caenorhabditis elegans through the insulin/IGF-1 signaling pathway. This is a preview...
Caenorhabditis elegans has been used as a major model organism to identify genetic factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) regulates aging in many species, ranging from nematodes to humans. C. elegans is a nonpathogenic ...
The role of insulin and IGF-1 signaling in longevity There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role ... M Katic,CR Kahn - 《Cellular & Molecular Life Sciences Cmls》 被引量: 333发表: ...
SHC-1 acts upstream of the insulin/IGF receptor DAF-2 and the PI3 kinase AGE-1 and directly interacts with DAF-2. Moreover, SHC-1 activates JNK signaling by binding to MEK-1 kinase. Both aspects converge on controlling the nuclear translocation and activation of the FOXO transcription factor...
Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH
1. Introduction 2. Insulin and IGF signalling in the brain 3. Neurodevelopmental disorders 4. Neuropsychiatric disorders 5. Conclusions CRediT authorship contribution statement Declaration of Competing Interest Acknowledgements ReferencesShow full outline Cited by (9) Figures (1) Tables (1) Table 1Neuro...