Using molecular dynamics simulation analysis, we find a small natural compound, XLIX, that inhibits the interaction of WDR6 with PPP1CB, thus reducing DNL in IR states. Together, these results reveal WDR6 as a promising target for the treatment of hepatic steatosis....
False-positive result of systemic lupus erythematosus latex test induced by anti-insulin antibodySjogren's syndromec-ANCAcavitationbronchiolitis obliterans organising pneumoniaScand J Rheumatol. 2000;29(4):270-1. Case Reports; Letterdoi:10.1080/030097400750041451...
d Representative images showing loss of PDX1LOW cells in B-hMAT islets (detected using a PDX1 antibody with reactivity against mouse and human protein) (scale bar = 42.5 µm). e PDX1 and INS1 are positively correlated in individual cells from B-hNORM islets (n = 220 ...
In general, antibody titers fall when highly purified insulins are used, but they sometimes persist after the switch. Some diseases, such as infections, endocrine hyperfunctional states (acromegaly, Cushing’s syndrome, thyrotoxicosis), leukemia, or stress, can contribute to insulin resistance. ...
温州科淼生物科技有限公司(Whenzhou KeMiao Biological Technology Co.,Ltd)是一家专业从事“产品研发生产,市场销售,技术服务”为一体的高科技生物技术公司,致力于为科研实验服务,主要产品为抗体、试剂盒、细胞、生化试剂等其他相关试剂。 抗体(antibody)是生物体在抗原物质刺激下,由B细胞分化成的浆细胞所产生的、可与...
Lawrence JC, Hiken JF, Inkster M, Scott CW, Mumby MC (1986) Insulin stimulates the generation of an adipocyte phosphoprotein that is isolated with a monoclonal antibody against the regulatory subunit of bovine heart cAMP-dependent protein kinase. Proc Natl Acad Sci U S A 83:3649–3653 CAS ...
antibody GHR: growth hormone receptor Gr: Group IC: interstitial cells IGFR: type 1 IGF receptor IR: insulin receptor LC: Leydig cell rhIGF-I: recombinant human type 1 insulin-like growth factor T: testosterone References Prince FP 2001 The triphasic nature of Leydig cell developme...
Mouse Anti-Mouse IgG Monoclonal Antibody价格:价格电议产品详情:温馨提示:优宁维所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! ... 纯度:见优宁维官网% 包装规格:见优宁维官网 用途:详见说明书
The same blot was reprobed with anti-GAPDH, Hsp90, or β-actin antibody to verify sample loading. The image of each western blot was scanned. The density of target band was quantified using Image J software (NIH) and then normalized by the density of GAPDH, Hsp90, or β-actin in the...
(RT) with pre-warmed 4% paraformaldehyde in PBS, washed three times with PBS, blocked for 90 min at RT with a blocking solution (3.0% foetal bovine serum/0.1% Triton X-100 in PBS) and incubated with rabbit anti-IR β antibody (Cell Signaling (4B8); 1:300 dilution in the blocking...