Exogenous insulin antibody syndrome (EIAS) has until recently been a rarely described complication of exogenous insulin therapy. EIAS results not only in hyperglycemia, but also in hypoglycemia and occasionally in ketoacidosis (DKA). The incidence of EIAS is increasing probably due to an overall ...
Obesity, type 2 diabetes mellitus and the metabolic syndrome are major risk factors for cardiovascular disease. Studies have demonstrated an association between low levels of testosterone and the above insulin-resistant states, with a prevalence of hypogonadism of up to 50% in men with type 2 diabe...
The longitudinal change of the k1/b1 population suggests a clonal change of the B cells producing the insulin antibody in insulin autoimmune syndrome. 展开 关键词: INSULIN ANTIBODY SCATCHARD ANALYSIS HYPOGLYCEMIC ATTACK DOI: 10.3109/08916939409071354 ...
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They also raise the possibility that long-term DHEA replacement therapy might reduce the accumulation of abdominal fat and protect against development of the metabolic/insulin resistance syndrome. An improvement in insulin action has also been reported by Kawano et al24 in a study of the effect of...
Type B insulin resistance syndrome is characterized by the presence of a circulating anti-insulin receptor antibody which inhibits insulin action. The syndrome is usually associated with autoimmune diseases, acanthosis nigricans and hyperinsulinemia. The antibody causes insulin resistance by inhibiting insulin...
Reaven G. The metabolic syndrome or the insulin resisvntance syndrome? Different names, different concepts, and different goals. Endocrinol Metab Clin North Am. 2004;33:283–303. CrossRef DeFronzo RA. Banting Lecture: from the triumvirate to the ominous Octet June 2008, American Diabetes Associa...
The presence of high levels of IAs, associated with random hypoglycemia in insulin-naive patients, is termed insulin autoimmune syndrome or Hirata disease (3,4). In some cases, postprandial hyperglycemia (insulin bound to antibody) and fasting hypoglycemia (disassociation of bound insulin from ...
Hepatic insulin resistance is central to the metabolic syndrome. Here we investigate the role of BTB and CNC homology 1 (BACH1) in hepatic insulin signaling. BACH1 is elevated in the hepatocytes of individuals with obesity and patients with non-alcoholic fatty liver disease (NAFLD). Hepatocyte-...
L. Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome. Exp. Mol. Med. 47, e149 (2015). CAS PubMed PubMed Central Google Scholar Young, S. E., Mainous, A. G. 3rd & Carnemolla, M. Hyperinsulinemia and cognitive decline in a ...