After the discovery of insulin, a century ago, extensive work has been done to unravel the molecular network regulating insulin secretion. Here we performed a chemical screen and identified AZD7762, a compound that potentiates glucose-stimulated insulin secretion (GSIS) of a human β cell line, h...
1. a hormone, produced by the beta cells of the islets of Langerhans of the pancreas, that regulates the metabolism of glucose and other nutrients. 2. any of several commercial preparations of this substance, each absorbed into the body at a particular rate: used for treating diabetes. [...
What is the relationship between homeostasis and diabetes? Explain how the pancreas belongs to both the digestive system and the endocrine system. Describe its function in each. What is the function of the pancreas? Explain how and why a single bout of aerobic exercise causes blood glucose levels...
Glucose-insulin-potassium (GIP), a potent cardioprotective intervention, has been demonstrated to adjust blood glucose (BG) levels and reduce lactate levels. However, the insulin-glucose ratio should be adjusted according to the surgery performed. Here, we aimed to evaluate the advantages of using ...
Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients. Diabetologia. 2008;51(2):309-319. doi:10.1007/s00125-007-0862-2 PubMedGoogle ScholarCrossref...
Anthropometric indexes (including height, weight, waist circumference, hip circumference, and skins fold thickness at 5 fatty difference points on the Erdheim diagram), fasting plasma glucose and insulin concentration were recorded. The mean age was 57.0卤9.2 years. The insulin resistance index was ...
found that in individuals with IR, hepatic insulin signalling exhibited a proximal block from the level of the insulin receptor (INSR) through both glucose and lipogenesis pathways8. Hepatic steatosis is regarded as a secondary effect of systemic IR; for example, the lipid content of adipose ...
GLP-1 synergizes with glucose in regulating pancreatic β-cell function, including facilitating β-cell survival and insulin secretion. Though it has been widely accepted that phosphorylation is extremely important in regulating β-cell functions, our kn
regression analyses were performed for the following variables: time from insulin alteration to neurotransmitter measure, blood glucose and insulin plasma concentration, and homeostatic model assessment (HOMA) index, expressed as the ratio between the levels in cases and controls. Meta-regression analyses...
Supplementary Figure 7 Schematic diagram showing the regulation of p35 protein dynamics and relationship with neuronal function. (A) Under normal physiological conditions, hexokinase-2 (HK2) catalyzes the formation of glucose-6-phosphate (G6P) form glucose. G6P then activates the MondoA-MLX complex...