The administration of warfarin requires frequent INR monitoring to ensure anticoagulation is within the therapeutic range. However, the therapeutic range of warfarin is narrow and has a large inter-patient variability, and there is no identical optimal level of anticoagulation (target INR) for different...
(PTLab/INRLab = 43 s/4.3). The delay in the rise of G for the patient on Coumadin therapy can be explained by the delay in the conversion of fibrinogen to fibrin, as it is well known that Coumadin inhibits the synthesis of the active form of vitamin K dependent pro-coagulation...