The latter 2 groups were also divided into two whether they had vitamin K at a later stage (B). There was not a meaningful relationship between those different trends of INR and factors such as other blood values (haemoglobin, urea, and glucose), medications and dehydration. Additionally, ...
The prothrombin time (PT) assay is the most clinically ordered coagulation test and is most often used for monitoring of vitamin K antagonist (VKA) therapy... EJ Favaloro,DM Adcock - 《Seminars in Thrombosis & Hemostasis》 被引量: 171发表: 2008年 Validation of the international normalized rati...
(June 2008) Ansell J, et al. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).Chest. 2008 Jun;133(6 Suppl):160S-198S. Available online through https://www.ncbi.nlm.nih.gov. Accessed August...
is thought to be high, switching to a non-vitamin K antagonist oral anticoagulants (NOAC) is reasonable. A patient who has difficulty having blood drawn is an example … Warfarin, when used as the anticoagulant, should be titrated to the lowest possible international normalized ratio (INR) leve...
If the patient’s INR was greater than 3 then vitamin K1 was administered or warfarin was temporarily stopped and the INR was tested again the next day. Patients routinely re-visited our institution for blood tests, coagulation function, ECG, chest radiograph and echocardiogram at 3 months after...
The indicated dose of 4-factor prothrombin complex concentrate (4F-PCC) for urgent vitamin K antagonist (VKA) reversal in patients with an international normalized ratio (INR) of 2 to 4 is 25 IU/kg, but there is no indicated dose for INR <2. We explored 4F-PCC dosing strategies for bas...
Depression of liver microsomal vitamin K epoxide reductase activity associated with antibiotic-induced coagulopathy[J]. Biochem Pharmacol, 1989, 38(16): 2693-2701. [5] 朱爱华 , 时晶 , 倪敬年 . 头孢哌酮钠 / 舒巴坦钠致凝血功能异常 [J]. 药物不良反应杂志 , 2011, 13(6):373-374. [6] 卢程 ...
Oral anticoagulant therapies with the anti-vitamin K drugs (AVK), warfarin, acenocoumarol and phenprocoumon, are employed in primary and secondary anti-thrombotic prophylaxis in patients with venous thromboembolism, atrial fibrillation and cardiac mechan
Spontaneous bleeding was seen in seven patients (6 major and 1 minor). Among the seven patients with bleeding, other than stopping he oral anticoagulant drug, other measures taken were vitamin K therapy, fresh frozen plasma or packed red cell transfusion. Overall management strategy of patients ...
conversion of fibrinogen to fibrin, as it is well known that Coumadin inhibits the synthesis of the active form of vitamin K dependent pro-coagulation factors such as Factors II, VII, IX, and X23which are essential for catalyzing fibrin formation. We further observed that the plateau modulus...