Our lineage analysis shows that all regions of the otic placode and otocyst can give rise to the sensory organs of the inner ear, though there were differences between labeled quadrants in the range of derivatives formed. A given region often gives rise to cells in multiple sensory organs, ...
s at E10.5; (ii) the endolymphatic duct is absent; and (iii) development of the semi-circular canals appear to abort at the end of the second week of gestation, resulting in the formation of only two partitions that correspond to the vestibular and the cochlear parts of the inner ear. ...
ARTICLE Received 21 Feb 2016 | Accepted 3 Oct 2016 | Published 18 Nov 2016 DOI: 10.1038/ncomms13458 OPEN An elastic element in the protocadherin-15 tip link of the inner ear Raul Araya-Secchi1, Brandon L. Neel1 & Marcos Sotomayor1 Tip link filaments convey force and gate inner-ear hair...
www.nature.com/scientificreports OPEN Exploring regulatory networks of miR-96 in the developing inner ear received: 07 December 2015 accepted: 24 February 2016 Published: 18 March 2016 Morag A. Lewis1,2, Annalisa Buniello1,2, Jennifer M. Hilton2, Fei Zhu2, William I. ...
The robust expression of BMP4 in the incipient sensory organs of the inner ear suggests possible roles for this signaling protein during induction and development of auditory and vestibular sensory epithelia. Homozygous BMP4-/- animals die before the inner ear's sensory organs develop, which preclud...
The Ear Worm Test Another reason why I went back to my first idea is that I found myself humming it in my head every day while none of the others really stuck with me. I’d be cooking eggs, and in my head singing “I don’t know where I’m going, Hardly know from where I ca...
Magnetically-targeted, technetium 99m-labeled nanoparticles to the inner earNANOPARTICLEPLGACOCHLEAMAGNETICTECHNETIUMRADIONUCLIDEThe cochlea presents a hurdle for intravascular drug therapy because of the blood-labyrinthine barrier that tends to exclude entry of large molecules from its vasculature. Magnetic ...
Study Design: Mouse inner ear specimens were fixed with minimal dissection, rapidly decalcified and fluorescently labeled by immunohistochemistry then impregnated by epoxy resin or a clearing agent composed of 5 parts methyl salicylate:3 parts benzyl benzoate. The specimens were imaged by both confocal...
Fig. 1. Expression of Emx2 in the inner ear. A) Little or no expression was detected in the otocyst at E10.5. B) In the cochlear duct at E12.5 the lateral, sensory region of the cochlear epithelium was labeled (between arrowheads) and there was detectable label in the roof of the du...
We found that shiverer-like membranes were devoid of MBP but labeled for the major compact myelin protein, PLP. Interestingly, the density of labeling of MBP on compact myelin profiles was similar in control and iKO, but the compact myelin surface area was significantly smaller in the iKO, ...