innate immune responseinterferonnitric oxide synthasepicornavirus infectionRNA ligandsWhen viruses enter the host, they are first detected by the innate immune system, which comprises cytokines, sentinel cells (dendritic cells [DCs] and macrophages), complement, and natural killer (NK) cells. A second...
固有性(非特异性)免疫应答 (innateimmuneresponse) 概念:是生物体在种系发育和进化过程中借遗传因素而形 成的免疫防御功能 特点:先天性、非特异性、相对稳定、反应迅速、方式单 一、无记忆性 组成:组织屏障(皮肤粘膜、血脑、血胎屏障)、固有免 疫细胞(吞噬细胞、NK细胞)、固有免疫分子(补体、溶菌 酶……) INN...
Related to innate immune response:Adaptive immune response n. The component of the immune response that involves the innate immune system. American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mi...
第11章 固有免疫应答 innate immune response.ppt,一、发生机制 游离抗原 + 中等大小免疫复合物(沉积) IgG/IgM 活化补体 吸引中性粒细胞 血小板参与 抗原:内源性、外源性 抗体:IgG/M 免疫复合物沉积条件: 吞噬细胞功能低下 补体成分缺陷 血管活性胺类的作用:使血管内
The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, but not on the host. Toll-like receptors (TLRs) recognize PAMPs and mediate the production of cytokines necessary for the development of effective immunity1,2,3,4. Flagellin,...
Mechanisms of mtDNA release and its effects on innate immune response. The release of mtDNA from mitochondria into the cytosol is triggered by different factors, including radiation exposure, microbial infection, inflammatory conditions, toxic substances or drugs, and gene mutation or deletion. Under ap...
The immune response in the brain has been widely investigated and while many studies have focused on the proinflammatory cytotoxic response, the brain’s innate immune system demonstrates significant heterogeneity. Microglia, like other tissue macrophages, participate in repair and resolution processes after...
The innate immune response is of prime importance in the immediate recognition and elimination of invading micro-organisms. However, deregulation of this system is clearly associated with the pathogenesis of a wide range of inflammatory diseases. Innate immunity consists of a humoral and a cellular ...
The study of how picornaviruses interact with the innate immune system is in its infancy. Understanding innate signaling pathways and how viruses counteract them should be a productive area of research for many years. 展开 关键词: encephalomyocarditis virus infection innate immune response interferon ...
Common genetic variants across individuals modulate the cellular response to pathogens and are implicated in diverse immune pathologies, yet how they dynamically alter the response upon infection is not well understood. Here, we triggered antiviral respo