innate immune responseinterferonnitric oxide synthasepicornavirus infectionRNA ligandsWhen viruses enter the host, they are first detected by the innate immune system, which comprises cytokines, sentinel cells (dendritic cells [DCs] and macrophages), complement, and natural killer (NK) cells. A second...
The innate immune response is a cell-autonomous program that induces an antiviral state in infected and nearby cells and alerts the immune system of the invading pathogen1. Dysregulation of this response can affect a wide range of inflammatory and autoimmune diseases and determine the outcome of in...
Trauma can affect any individual at any location and at any time over a lifespan. The disruption of macrobarriers and microbarriers induces instant activation of innate immunity. The subsequent complex response, designed to limit further damage and induc
1.1. Innate immune response and inflammosome activation The innate immune response is an evolutionary conserved component of immune system that acts as a first line of defense against harmful stimuli [13]. Innate immune response is activated by intracellular or surface-expressed pattern recognition rec...
(innateimmuneresponse) 概念:是生物体在种系发育和进化过程中借遗传因素而形成的免疫防御功能 特点:先天性、非特异性、相对稳定、反应迅速、方式单一、无记忆性 组成:组织屏障(皮肤粘膜、血脑、血胎屏障)、固有免疫细胞(吞噬细胞、NK细胞)、固有免疫分子(补体、溶菌酶……) ...
A review of the innate immune system, utilizing the concepts of cellular and molecular biology. Covers all aspects of innate immunity with an emphasis on response to infectious agents. Focuses on evolutionary aspects, describing the major cells, humoral factors, receptors, and effector responses centr...
interplay between the innate and the adaptive immune system is significant, and it therefore sometimes difficult to draw a sharp line between the two. All components of the innate immune system are part of theinflammatory response. It is therefore hardly surprising, that all factors of the innate...
Related to innate immune response:Adaptive immune response n. The component of the immune response that involves the innate immune system. American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mi...
Innate Immune Response (Ch14) Overview of Innate Defense System First lines of Defense Physical Barriers Antimicrobial substances Skin Mucous membranes Antimicrobial substances Lysozyme Peroxidase enzyme Lactoferrin Defensins Normal Flora Epithelial Barriers ...
InnateDB is a publicly available database of the genes, proteins, experimentally-verified interactions and signaling pathways involved in the innate immune response of humans, mice and bovines to microbial infection. The database captures an improved cov